Genome-wide association studies for milk production traits in Valle del Belice sheep using repeated measures

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Abstract

Genome-wide association studies (GWASes) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWASes as a methodology and has not been implemented. The aim of this study was to carry out a GWAS for milk production traits in Valle del Belice sheep using repeated measures. After quality control, 469 ewes and 37 228 SNPs were retained for the analysis, and phenotypic data included 5586 test-day records for five milk production traits (milk yield, MY; fat yield and percentage, FY and F%; protein yield and percentage, PY and P%). Nine SNPs located within or close to known genes were found to be associated with milk production traits. In particular, rs398340969, associated with both milk yield and protein yield, is located within the DCPS gene. In addition, rs425417915 and rs417079368, both associated with both fat percentage and protein percentage, are located within the TTC7B gene and at 0.37 Mb within the SUCNR1 gene respectively. In summary, the use of repeated records was beneficial for mapping genomic regions affecting milk production traits in the Valle del Belice sheep.
Lingua originaleEnglish
pagine (da-a)311-314
Numero di pagine4
RivistaAnimal Genetics
Volume50
Stato di pubblicazionePublished - 2019

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Genome-Wide Association Study
milk production
Sheep
Milk
sheep
milk yield
genes
Genes
Single Nucleotide Polymorphism
genomics
Fats
dairy sheep
proteins
lipids
Milk Proteins
Livestock
quality control
ewes
Quality Control
livestock

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Genetics

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@article{c69ceb2fe4d54bfe9f965652b3f133aa,
title = "Genome-wide association studies for milk production traits in Valle del Belice sheep using repeated measures",
abstract = "Genome-wide association studies (GWASes) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWASes as a methodology and has not been implemented. The aim of this study was to carry out a GWAS for milk production traits in Valle del Belice sheep using repeated measures. After quality control, 469 ewes and 37 228 SNPs were retained for the analysis, and phenotypic data included 5586 test-day records for five milk production traits (milk yield, MY; fat yield and percentage, FY and F{\%}; protein yield and percentage, PY and P{\%}). Nine SNPs located within or close to known genes were found to be associated with milk production traits. In particular, rs398340969, associated with both milk yield and protein yield, is located within the DCPS gene. In addition, rs425417915 and rs417079368, both associated with both fat percentage and protein percentage, are located within the TTC7B gene and at 0.37 Mb within the SUCNR1 gene respectively. In summary, the use of repeated records was beneficial for mapping genomic regions affecting milk production traits in the Valle del Belice sheep.",
author = "Sutera, {Anna Maria} and Sardina, {Maria Teresa} and Baldassare Portolano and Salvatore Mastrangelo and Marco Tolone and {Di Gerlando}, Rosalia and Riggio and Pong-Wong",
year = "2019",
language = "English",
volume = "50",
pages = "311--314",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Genome-wide association studies for milk production traits in Valle del Belice sheep using repeated measures

AU - Sutera, Anna Maria

AU - Sardina, Maria Teresa

AU - Portolano, Baldassare

AU - Mastrangelo, Salvatore

AU - Tolone, Marco

AU - Di Gerlando, Rosalia

AU - Riggio, null

AU - Pong-Wong, null

PY - 2019

Y1 - 2019

N2 - Genome-wide association studies (GWASes) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWASes as a methodology and has not been implemented. The aim of this study was to carry out a GWAS for milk production traits in Valle del Belice sheep using repeated measures. After quality control, 469 ewes and 37 228 SNPs were retained for the analysis, and phenotypic data included 5586 test-day records for five milk production traits (milk yield, MY; fat yield and percentage, FY and F%; protein yield and percentage, PY and P%). Nine SNPs located within or close to known genes were found to be associated with milk production traits. In particular, rs398340969, associated with both milk yield and protein yield, is located within the DCPS gene. In addition, rs425417915 and rs417079368, both associated with both fat percentage and protein percentage, are located within the TTC7B gene and at 0.37 Mb within the SUCNR1 gene respectively. In summary, the use of repeated records was beneficial for mapping genomic regions affecting milk production traits in the Valle del Belice sheep.

AB - Genome-wide association studies (GWASes) have become a powerful tool for identifying genomic regions associated with important traits in livestock. Milk production traits in dairy sheep are measured at different time points during their life span. Using phenotypic data generated from longitudinal traits could improve the power of association studies but until now have received less attention in GWASes as a methodology and has not been implemented. The aim of this study was to carry out a GWAS for milk production traits in Valle del Belice sheep using repeated measures. After quality control, 469 ewes and 37 228 SNPs were retained for the analysis, and phenotypic data included 5586 test-day records for five milk production traits (milk yield, MY; fat yield and percentage, FY and F%; protein yield and percentage, PY and P%). Nine SNPs located within or close to known genes were found to be associated with milk production traits. In particular, rs398340969, associated with both milk yield and protein yield, is located within the DCPS gene. In addition, rs425417915 and rs417079368, both associated with both fat percentage and protein percentage, are located within the TTC7B gene and at 0.37 Mb within the SUCNR1 gene respectively. In summary, the use of repeated records was beneficial for mapping genomic regions affecting milk production traits in the Valle del Belice sheep.

UR - http://hdl.handle.net/10447/354662

UR - https://onlinelibrary.wiley.com/doi/10.1111/age.12789

M3 - Article

VL - 50

SP - 311

EP - 314

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

ER -