Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study

Giuseppe Licata, Salvatore Corrao, Angela Alibrandi, Diego Pancaldo, Giacoma Di Vieste, Alessandra Bitto, Diego Pancaldo, Roberta Granese, Vincenzo Arcoraci, Elena Bianca Adamo, Herbert Marini, Cesare De Gregorio, Concetta Irace, Salvatore Corrao, Antonino Di Benedetto, Francesco Squadrito, Domenica Altavilla, Marco Atteritano

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Abstract

Genistein, a soy-derived isoflavone,may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. -1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.
Lingua originaleEnglish
pagine (da-a)584-
Numero di pagine11
RivistaNutrients
Volume9
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

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Licata, G., Corrao, S., Alibrandi, A., Pancaldo, D., Di Vieste, G., Bitto, A., Pancaldo, D., Granese, R., Arcoraci, V., Adamo, E. B., Marini, H., De Gregorio, C., Irace, C., Corrao, S., Di Benedetto, A., Squadrito, F., Altavilla, D., & Atteritano, M. (2017). Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study. Nutrients, 9, 584-.