Genistein and endothelial function in postmenopausal women with metabolic syndrome

Salvatore Corrao, Giuseppe Licata, Francesca Polito, Giacoma Di Vieste, Alessandra Bitto, Letteria Minutoli, Vincenzo Arcoraci, Elena Bianca Adamo, Herbert Marini, Cesare De Gregorio, Concetta Irace, Antonino Di Benedetto, Francesco Squadrito, Domenica Altavilla, Agostino Gnasso

Risultato della ricerca: Article

29 Citazioni (Scopus)

Abstract

BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brachial artery; moreover, time-to-peak dilation in the FMD response has been evaluated. Secondary outcomes were fasting glucose, fasting insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, visfatin, adiponectin and homocysteine blood levels. Data on adverse events were also recorded. ResultsAfter 6months of treatment, FMD at 50s and peak FMD significantly increased in genistein recipients compared with placebo. Moreover, genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased. Genistein recipients neither experienced more side-adverse effects than placebo nor discontinued the study. ConclusionsSix months of treatment with genistein effectively improves brachial artery flow-mediated vasodilation in postmenopausal women with metabolic syndrome.
Lingua originaleEnglish
pagine (da-a)1025-1031
Numero di pagine7
RivistaEuropean Journal of Clinical Investigation
Volume43
Stato di pubblicazionePublished - 2013

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Genistein
Vasodilation
Nicotinamide Phosphoribosyltransferase
Blood
Brachial Artery
Adiponectin
Placebos
Homocysteine
Fasting
Triglycerides
Cholesterol
Mediterranean Diet
Placebo Effect
Nutrition
LDL Cholesterol
HDL Cholesterol
Dilatation
Randomized Controlled Trials
Adenosine Triphosphate
Insulin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry

Cita questo

Genistein and endothelial function in postmenopausal women with metabolic syndrome. / Corrao, Salvatore; Licata, Giuseppe; Polito, Francesca; Di Vieste, Giacoma; Bitto, Alessandra; Minutoli, Letteria; Arcoraci, Vincenzo; Adamo, Elena Bianca; Marini, Herbert; De Gregorio, Cesare; Irace, Concetta; Di Benedetto, Antonino; Squadrito, Francesco; Altavilla, Domenica; Gnasso, Agostino.

In: European Journal of Clinical Investigation, Vol. 43, 2013, pag. 1025-1031.

Risultato della ricerca: Article

Corrao, S, Licata, G, Polito, F, Di Vieste, G, Bitto, A, Minutoli, L, Arcoraci, V, Adamo, EB, Marini, H, De Gregorio, C, Irace, C, Di Benedetto, A, Squadrito, F, Altavilla, D & Gnasso, A 2013, 'Genistein and endothelial function in postmenopausal women with metabolic syndrome', European Journal of Clinical Investigation, vol. 43, pagg. 1025-1031.
Corrao, Salvatore ; Licata, Giuseppe ; Polito, Francesca ; Di Vieste, Giacoma ; Bitto, Alessandra ; Minutoli, Letteria ; Arcoraci, Vincenzo ; Adamo, Elena Bianca ; Marini, Herbert ; De Gregorio, Cesare ; Irace, Concetta ; Di Benedetto, Antonino ; Squadrito, Francesco ; Altavilla, Domenica ; Gnasso, Agostino. / Genistein and endothelial function in postmenopausal women with metabolic syndrome. In: European Journal of Clinical Investigation. 2013 ; Vol. 43. pagg. 1025-1031.
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abstract = "BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brachial artery; moreover, time-to-peak dilation in the FMD response has been evaluated. Secondary outcomes were fasting glucose, fasting insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, visfatin, adiponectin and homocysteine blood levels. Data on adverse events were also recorded. ResultsAfter 6months of treatment, FMD at 50s and peak FMD significantly increased in genistein recipients compared with placebo. Moreover, genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased. Genistein recipients neither experienced more side-adverse effects than placebo nor discontinued the study. ConclusionsSix months of treatment with genistein effectively improves brachial artery flow-mediated vasodilation in postmenopausal women with metabolic syndrome.",
keywords = "Clinical study, endothelial function, genistein, menopause, metabolic syndrome",
author = "Salvatore Corrao and Giuseppe Licata and Francesca Polito and {Di Vieste}, Giacoma and Alessandra Bitto and Letteria Minutoli and Vincenzo Arcoraci and Adamo, {Elena Bianca} and Herbert Marini and {De Gregorio}, Cesare and Concetta Irace and {Di Benedetto}, Antonino and Francesco Squadrito and Domenica Altavilla and Agostino Gnasso",
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T1 - Genistein and endothelial function in postmenopausal women with metabolic syndrome

AU - Corrao, Salvatore

AU - Licata, Giuseppe

AU - Polito, Francesca

AU - Di Vieste, Giacoma

AU - Bitto, Alessandra

AU - Minutoli, Letteria

AU - Arcoraci, Vincenzo

AU - Adamo, Elena Bianca

AU - Marini, Herbert

AU - De Gregorio, Cesare

AU - Irace, Concetta

AU - Di Benedetto, Antonino

AU - Squadrito, Francesco

AU - Altavilla, Domenica

AU - Gnasso, Agostino

PY - 2013

Y1 - 2013

N2 - BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brachial artery; moreover, time-to-peak dilation in the FMD response has been evaluated. Secondary outcomes were fasting glucose, fasting insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, visfatin, adiponectin and homocysteine blood levels. Data on adverse events were also recorded. ResultsAfter 6months of treatment, FMD at 50s and peak FMD significantly increased in genistein recipients compared with placebo. Moreover, genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased. Genistein recipients neither experienced more side-adverse effects than placebo nor discontinued the study. ConclusionsSix months of treatment with genistein effectively improves brachial artery flow-mediated vasodilation in postmenopausal women with metabolic syndrome.

AB - BackgroundPrevious data have suggested that genistein could exert beneficial effects on endothelial function and on predictors of cardiovascular risk in healthy postmenopausal women. In a randomized clinical trial, we studied the effects of genistein on endothelial function in postmenopausal women with metabolic syndrome (MS). MethodsTwenty postmenopausal women with MS, according to modified NCEP-ATP III criteria were randomly assigned to receive placebo or genistein (54mg/day) for 6months, along with a Mediterranean-style diet. Postmenopausal women without MS (n=15), served as controls. The primary goal was the assessment of endothelial function by flow-mediated vasodilation (FMD) of brachial artery; moreover, time-to-peak dilation in the FMD response has been evaluated. Secondary outcomes were fasting glucose, fasting insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, visfatin, adiponectin and homocysteine blood levels. Data on adverse events were also recorded. ResultsAfter 6months of treatment, FMD at 50s and peak FMD significantly increased in genistein recipients compared with placebo. Moreover, genistein significantly decreased the blood levels of total cholesterol, triglycerides, homocysteine and visfatin compared with placebo, while blood adiponectin levels were increased. Genistein recipients neither experienced more side-adverse effects than placebo nor discontinued the study. ConclusionsSix months of treatment with genistein effectively improves brachial artery flow-mediated vasodilation in postmenopausal women with metabolic syndrome.

KW - Clinical study

KW - endothelial function

KW - genistein

KW - menopause

KW - metabolic syndrome

UR - http://hdl.handle.net/10447/121270

M3 - Article

VL - 43

SP - 1025

EP - 1031

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

ER -