Genetic Control of Immune Response in Carriers of the 8.1 Ancestral Haplotype: Correlation with Levels of IgG Subclasses: Its Relevance in the Pathogenesis of Autoimmune Diseases

Calogero Caruso, Giuseppina Candore, Irene Cuppari, Anna Maria Campagna, Daniele D.I. Carlo, Claudia Mineo, Calogero Caruso, Anna Maria Campagna, Daniele Di Carlo, Irene Cuppari

Risultato della ricerca: Article

14 Citazioni (Scopus)

Abstract

Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we demonstrate that IgG2 serum levels were significantly lower in 8.1 AH carriers than in 8.1 AH non-carriers. On the contrary, as regards IgG1, IgG3, IgG4 serum levels, no significant differences were observed between the two groups. In AH 8.1 carriers low IgG2 levels might take to slower clearance of the infectious agent and hence to a lasting presence of it. The persistence of infectious antigens could determine an increased production of autoantibodies with a higher risk of cross-reactions.
Lingua originaleEnglish
pagine (da-a)151-158
Numero di pagine8
RivistaAnnals of the New York Academy of Sciences
Volume1110
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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