Genes, ageing and longevity in humans: problems, advantages and perspectives

Calogero Caruso, Cevenini, Celani, Sevini, Gonos, Claudio Franceschi, Michele Mishto, Francesca Marchegiani, Silvana Valensin, Maurizio Cardelli, Fabiola Olivieri, Salvioli, Miriam Capri, De Benedictis, Monti, Giuseppe Paolisso, Francesco Lescai, Invidia, Elena Bellavista, Aurelia SantoroLaura Invidia

Risultato della ricerca: Articlepeer review

65 Citazioni (Scopus)


Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the study of centenarians, the best example of successful ageing. We review the main results regarding nuclear genes as well as the mitochondrial genome, focusing on the investigations performed on Italian centenarians, compared to those from other countries. These studies produced interesting results on many putative "longevity genes". Nevertheless, many discrepancies are reported, likely due to the population-specific interactions between gene pools and environment. New approaches, including large-scale studies using high-throughput techniques, are urgently needed to overcome the limits of traditional association studies performed on a limited number of polymorphisms in order to make substantial progress to disentangle the genetics of a trait as complex as human longevity.
Lingua originaleEnglish
pagine (da-a)1303-1323
Numero di pagine21
RivistaFree Radical Research
Stato di pubblicazionePublished - 2006

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