Gene therapy for type 1 diabetes: is it ready for the clinic?

Antonella D'Anneo, Jing He, Antonella D'Anneo, Jing He, Antonella D'Anneo, Antonella D'Anneo, Nick Giannoukakis, Rita Bottino, Balamurugan, Pleunie Rood

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)


This review, in addition to updating the growing list of type 1 diabetes–relevant gene therapies, offers an outline of short-term objectives that can readily be met to move, at least, adenoviral and adeno-associated viral-based protocols into the clinic, first as a means of facilitating islet allografts as well as platforms with whichto introduce immunoregulatory transgenes. A wide array of genes have been tested to restore insulin production, to drive the differentiation of insulin-producing progenitors, and to confer immunosuppression in an antigen- and tissue-restricted manner.
Lingua originaleEnglish
pagine (da-a)83-89
Numero di pagine7
RivistaImmunologic Research
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Immunology

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