Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program

Claudio Luparello, Liana Bosco, Maria Carmela Roccheri, Monica Lispi, Stefania Ferrari, Daniele Santi, Stefania Ferrari, Domenico Valerio, Stefania Ferrari, Stefania Ferrari, Giovanni Ruvolo, Paola Piomboni, Elena Sarcina

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

FSH receptor (FSHR) Ala307Thr and Asn680Ser and LHβ chain (LHB) Trp28Arg and Ile35Thr polymorphisms affect the response to pharmacological ovarian stimulation with r-FSH in women undergoing assisted reproductive treatment (ART). Here, we evaluated the expression level of selected genes involved in follicle maturation and the possible onset of apoptosis in cumulus cells of patients with single and double FSHR and LHB polymorphisms, as potential markers of oocyte competence.
Lingua originaleEnglish
pagine (da-a)2391-2404
Numero di pagine14
RivistaCellular Physiology and Biochemistry
Volume43
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Physiology

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