Gender-Related Immune-Inflammatory Factors,Age-Related Diseases, and Longevity

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24 Citazioni (Scopus)


This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses.In particular, their role in Alzheimer’s disease (AD), an example of immune-inflammatory disease, isdiscussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts for themajority of cases of clinical senile dementia. However, sexual dimorphism of diseases may also depend onfactors independent of sex hormones (i.e., a gender effect), as demonstrated by our data on differential longevityin females and males. In fact, differences in mortality between men and women are not only a question of sexthat refers to biological differences, but rather a question of ‘‘socially constructed sex,’’ a question of gender(i.e., the characteristics that a society or culture delineates as masculine or feminine). In gender medicine, weconclude that it is important to consider the role played both by hormones, customs, and educational levelsregarding the different propensity of males and females to fall ill. So, in programming antiaging strategies, wehave also to take these aspects into account
Lingua originaleEnglish
pagine (da-a)292-297
Numero di pagine6
RivistaRejuvenation Research
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2717???


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