gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis

Nadia Rosalia Caccamo, Francesco Dieli, Guido Sireci, Alfredo Salerno, Serena Meraviglia, Alfredo Salerno, Juraj Ivanyi, Francesco Dieli

Risultato della ricerca: Article

35 Citazioni (Scopus)

Abstract

gammadelta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gammadelta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.
Lingua originaleEnglish
pagine (da-a)2681-2690
RivistaEuropean Journal of Immunology
Volume36
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Entra nei temi di ricerca di 'gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis'. Insieme formano una fingerprint unica.

Cita questo