gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis

Francesco Dieli, Nadia Rosalia Caccamo, Guido Sireci, Alfredo Salerno, Serena Meraviglia, Alfredo Salerno, Juraj Ivanyi, Francesco Dieli

Risultato della ricerca: Article

33 Citazioni (Scopus)

Abstract

gammadelta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gammadelta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.
Lingua originaleEnglish
pagine (da-a)2681-2690
RivistaEuropean Journal of Immunology
Volume36
Stato di pubblicazionePublished - 2006

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Mycobacterium tuberculosis
Dendritic Cells
T-Lymphocytes
Lung
Adaptive Immunity
Interleukin-12
Mycobacterium bovis
Vaccination
Vaccines
Bone Marrow
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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title = "gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis",
abstract = "gammadelta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gammadelta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.",
author = "Francesco Dieli and Caccamo, {Nadia Rosalia} and Guido Sireci and Alfredo Salerno and Serena Meraviglia and Alfredo Salerno and Juraj Ivanyi and Francesco Dieli",
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T1 - gd T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis

AU - Dieli, Francesco

AU - Caccamo, Nadia Rosalia

AU - Sireci, Guido

AU - Salerno, Alfredo

AU - Meraviglia, Serena

AU - Salerno, Alfredo

AU - Ivanyi, Juraj

AU - Dieli, Francesco

PY - 2006

Y1 - 2006

N2 - gammadelta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gammadelta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.

AB - gammadelta T cells and dendritic cells are quickly recruited to the lungs shortly after intranasal vaccination with BCG, but the functional in vivo interplay between these two cell populations and its role in the induction of adaptive immune responses is unclear. Using TCR-deficient mice and bone marrow chimeras, we show here that gammadelta T cells provide a non-redundant early source of IFN-gamma in vivo, which enhances IL-12 production by lung dendritic cells. The in vivo-conditioned dendritic cells, in turn, prime a more efficient lung CD8 T cell response against Mycobacterium tuberculosis. Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines.

UR - http://hdl.handle.net/10447/23157

M3 - Article

VL - 36

SP - 2681

EP - 2690

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

ER -