Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice.

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Abstract

Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although the length of the intestine was similar in both animals. The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions.
Lingua originaleEnglish
pagine (da-a)75-79
Numero di pagine5
RivistaJournal of Physiological Sciences
Volume60
Stato di pubblicazionePublished - 2010

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Inbred mdx Mouse
Gastric Emptying
Dystrophin
Duchenne Muscular Dystrophy
Phenolsulfonphthalein
Sarcolemma
Carboxymethylcellulose Sodium
Striated Muscle
Intestines
Smooth Muscle
Meals
Myocardium
Skeletal Muscle
Coloring Agents
Animal Models
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology

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title = "Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice.",
abstract = "Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although the length of the intestine was similar in both animals. The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions.",
keywords = "Duchenne muscular dystrophy, Fecal output, Gastric emptying, Intestinal transit, mdx mouse",
author = "Antonella Amato and Flavia Mule' and Serio, {Rosa Maria}",
year = "2010",
language = "English",
volume = "60",
pages = "75--79",
journal = "Journal of Physiological Sciences",
issn = "1880-6546",
publisher = "Springer Japan",

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TY - JOUR

T1 - Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice.

AU - Amato, Antonella

AU - Mule', Flavia

AU - Serio, Rosa Maria

PY - 2010

Y1 - 2010

N2 - Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although the length of the intestine was similar in both animals. The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions.

AB - Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although the length of the intestine was similar in both animals. The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions.

KW - Duchenne muscular dystrophy

KW - Fecal output

KW - Gastric emptying

KW - Intestinal transit

KW - mdx mouse

UR - http://hdl.handle.net/10447/44545

M3 - Article

VL - 60

SP - 75

EP - 79

JO - Journal of Physiological Sciences

JF - Journal of Physiological Sciences

SN - 1880-6546

ER -