GALACTOSE-DECORATED POLYMERIC CARRIERS FOR HEPATOCYTE-SELECTIVE DRUG TARGETING

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Abstract

In this paper, the current available strategies to realize galactose-decoratednanostructured polymeric systems are summarized. These carriers are designed in orderto obtain targeted drug delivery to hepatocytes via galactose (GAL) moieties, i.e., forthe treatment of viral hepatitis or liver cancer that are the greater causes of globaldisability and mortality. Usually, the main followed strategy to obtain galactosylatedpolymeric carriers is to use galactosylated copolymers. The chemical modifications ofpreformed polymers with sugar-containing reagents is followed for obtaininglactosaminated human albumin, galactosylated phospholipid-polyaminoacid andpolylactide (PLA)- polyaminoacid conjugates obtained from α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) or lactosaminated carboxymethyl chitosan(CMC). Galactosylated polymers are also obtained via the polymerization of GALbearingmonomers, that is for obtaining galactosylated polycarbonates. Finally, thesurface galactosylation of preformed polymeric carriers is an alternative strategy thatcan be used to obtain a GAL-decorated system, that is for obtaining dendrimers basedon polyamidoamine (PAMAM)-GAL conjugates.
Lingua originaleEnglish
Titolo della pubblicazione ospiteFRONTIERS IN NANOMEDICINE VOL 1
Pagine84-107
Numero di pagine24
Stato di pubblicazionePublished - 2015

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