Gadolinium-chelating nanogels as MR contrast agesnts specifically targeting tumor cells

Risultato della ricerca: Other

Abstract

Development of multifunctional nanogels coordinating paramagnetic ions and displacing targeting ligands for preferential accumulation into tumors.Low molecular-weight Gd-chelates are widely used in clinical MRI for various purposes. However, these contrast agents (CAs) have several shortcomings: they rapidly extravasate from blood vessels to the interstitial space, have a short circulation times and show poor contrast at high magnetic fields. Incorporating gadolinium into flexible nanogels has the potential of increasing intravascular half-life, accumulation and retention in specific body compartments of the CA as well as increasing the MR signal, since many metal ions can be coordinated to the same nanoparticle
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2014

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