Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 4003-4011 |
| Numero di pagine | 9 |
| Rivista | CURRENT PHARMACEUTICAL DESIGN |
| Volume | 23 |
| Stato di pubblicazione | Published - 2017 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Drug Discovery
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GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders. / Serio, Rosa Maria; Auteri, Michelangelo; Vlainić, Josipa; Jembrek, Maja Jazvinšćak.
In: CURRENT PHARMACEUTICAL DESIGN, Vol. 23, 2017, pag. 4003-4011.Risultato della ricerca: Article
}
TY - JOUR
T1 - GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders
AU - Serio, Rosa Maria
AU - Auteri, Michelangelo
AU - Vlainić, Josipa
AU - Jembrek, Maja Jazvinšćak
PY - 2017
Y1 - 2017
N2 - Background: Currently, treatment of stress-related gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), is mainly symptomatic since there is no drug on the market that solves effectively diverse disease symptoms and comorbid states. Recently GABA receptors have been identified within gastrointestinal system and it has been recognized that among various GABAergic drugs some of them influence gastrointestinal stress-related diseases. Among them benzodiazepines have been investigated due to their diverse effects: neuroimmunomodulatory, relief of visceral pain and anxiolytic action.Conclusion: The present review brings findings on the expression of GABA receptors in the gastrointestinal tract and the role of GABA within it. We also present knowledge on the role of neurotransmitter GABA and various GABAergic ligands on diverse physiologic gastrointestinal functions with special emphasize to stress-related disorders. The rationale for therapeutic use and further identification of a potential GABAergic treatment of stress-related disorders has been critically discussed.
AB - Background: Currently, treatment of stress-related gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), is mainly symptomatic since there is no drug on the market that solves effectively diverse disease symptoms and comorbid states. Recently GABA receptors have been identified within gastrointestinal system and it has been recognized that among various GABAergic drugs some of them influence gastrointestinal stress-related diseases. Among them benzodiazepines have been investigated due to their diverse effects: neuroimmunomodulatory, relief of visceral pain and anxiolytic action.Conclusion: The present review brings findings on the expression of GABA receptors in the gastrointestinal tract and the role of GABA within it. We also present knowledge on the role of neurotransmitter GABA and various GABAergic ligands on diverse physiologic gastrointestinal functions with special emphasize to stress-related disorders. The rationale for therapeutic use and further identification of a potential GABAergic treatment of stress-related disorders has been critically discussed.
KW - GABAergic system
KW - Stress
KW - benzodiazepines
KW - gastrointestinal system
KW - stress-related disorders
KW - therapy
UR - http://hdl.handle.net/10447/249848
M3 - Article
VL - 23
SP - 4003
EP - 4011
JO - CURRENT PHARMACEUTICAL DESIGN
JF - CURRENT PHARMACEUTICAL DESIGN
SN - 1381-6128
ER -