GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders

Michelangelo Auteri, Rosa Maria Serio, Josipa Vlainić, Maja Jazvinšćak Jembrek

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Background: Currently, treatment of stress-related gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), is mainly symptomatic since there is no drug on the market that solves effectively diverse disease symptoms and comorbid states. Recently GABA receptors have been identified within gastrointestinal system and it has been recognized that among various GABAergic drugs some of them influence gastrointestinal stress-related diseases. Among them benzodiazepines have been investigated due to their diverse effects: neuroimmunomodulatory, relief of visceral pain and anxiolytic action.Conclusion: The present review brings findings on the expression of GABA receptors in the gastrointestinal tract and the role of GABA within it. We also present knowledge on the role of neurotransmitter GABA and various GABAergic ligands on diverse physiologic gastrointestinal functions with special emphasize to stress-related disorders. The rationale for therapeutic use and further identification of a potential GABAergic treatment of stress-related disorders has been critically discussed.
Lingua originaleEnglish
pagine (da-a)4003-4011
Numero di pagine9
RivistaDefault journal
Volume23
Stato di pubblicazionePublished - 2017

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GABA Receptors
gamma-Aminobutyric Acid
Visceral Pain
Irritable Bowel Syndrome
Anti-Anxiety Agents
Therapeutic Uses
Benzodiazepines
Inflammatory Bowel Diseases
Pharmaceutical Preparations
Neurotransmitter Agents
Gastrointestinal Tract
Ligands
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders. / Auteri, Michelangelo; Serio, Rosa Maria; Vlainić, Josipa; Jembrek, Maja Jazvinšćak.

In: Default journal, Vol. 23, 2017, pag. 4003-4011.

Risultato della ricerca: Article

Auteri, Michelangelo ; Serio, Rosa Maria ; Vlainić, Josipa ; Jembrek, Maja Jazvinšćak. / GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders. In: Default journal. 2017 ; Vol. 23. pagg. 4003-4011.
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AB - Background: Currently, treatment of stress-related gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), is mainly symptomatic since there is no drug on the market that solves effectively diverse disease symptoms and comorbid states. Recently GABA receptors have been identified within gastrointestinal system and it has been recognized that among various GABAergic drugs some of them influence gastrointestinal stress-related diseases. Among them benzodiazepines have been investigated due to their diverse effects: neuroimmunomodulatory, relief of visceral pain and anxiolytic action.Conclusion: The present review brings findings on the expression of GABA receptors in the gastrointestinal tract and the role of GABA within it. We also present knowledge on the role of neurotransmitter GABA and various GABAergic ligands on diverse physiologic gastrointestinal functions with special emphasize to stress-related disorders. The rationale for therapeutic use and further identification of a potential GABAergic treatment of stress-related disorders has been critically discussed.

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