Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

Maurizio Bruno, Antonella Maria Maggio, Vivienne Spadaro, Sergio Rosselli, Carlo Irace, Nicola Mascolo, Carmen Formisano, Carmen Maffettone

Risultato della ricerca: Articlepeer review

14 Citazioni (Scopus)

Abstract

Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.
Lingua originaleEnglish
pagine (da-a)1243-1249
Numero di pagine7
RivistaPhytotherapy Research
Volume23
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2700???
  • Pharmacology

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