From microbial proteomics to synthetic biology: Amycolatopsis balhimycina case

Anna Maria Puglia, Rosa Alduina, Giuseppe Gallo, Andrea Scaloni, Giovanni Renzone

Risultato della ricerca: Paper

2 Citazioni (Scopus)

Abstract

Our investigation, performed by combining data from differential proteomic analyses carried-out using wild-type (Wt) and non-producing strains incubated in different growth conditions, showed that antibiotic production is always associated with the up-regulation of either specific enzymes of balhimycin (bal) biosynthetic gene cluster and enzymes related to central carbon metabolism, cell energy and redox balance. Thus this approach suggested new insights to improve fermentation technology strategies and revealed target genes for synthetic biology approaches aimed to improve antibiotic yield production.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2012

Fingerprint

Antibiotics
Enzymes
Genes
Anti-Bacterial Agents
Metabolism
Fermentation
Synthetic Biology
Proteomics
Oxidation-Reduction
balhimycin

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cita questo

@conference{1d61d4f4d6f347d787a26231ba748a6e,
title = "From microbial proteomics to synthetic biology: Amycolatopsis balhimycina case",
abstract = "Our investigation, performed by combining data from differential proteomic analyses carried-out using wild-type (Wt) and non-producing strains incubated in different growth conditions, showed that antibiotic production is always associated with the up-regulation of either specific enzymes of balhimycin (bal) biosynthetic gene cluster and enzymes related to central carbon metabolism, cell energy and redox balance. Thus this approach suggested new insights to improve fermentation technology strategies and revealed target genes for synthetic biology approaches aimed to improve antibiotic yield production.",
author = "Puglia, {Anna Maria} and Rosa Alduina and Giuseppe Gallo and Andrea Scaloni and Giovanni Renzone",
year = "2012",
language = "English",

}

TY - CONF

T1 - From microbial proteomics to synthetic biology: Amycolatopsis balhimycina case

AU - Puglia, Anna Maria

AU - Alduina, Rosa

AU - Gallo, Giuseppe

AU - Scaloni, Andrea

AU - Renzone, Giovanni

PY - 2012

Y1 - 2012

N2 - Our investigation, performed by combining data from differential proteomic analyses carried-out using wild-type (Wt) and non-producing strains incubated in different growth conditions, showed that antibiotic production is always associated with the up-regulation of either specific enzymes of balhimycin (bal) biosynthetic gene cluster and enzymes related to central carbon metabolism, cell energy and redox balance. Thus this approach suggested new insights to improve fermentation technology strategies and revealed target genes for synthetic biology approaches aimed to improve antibiotic yield production.

AB - Our investigation, performed by combining data from differential proteomic analyses carried-out using wild-type (Wt) and non-producing strains incubated in different growth conditions, showed that antibiotic production is always associated with the up-regulation of either specific enzymes of balhimycin (bal) biosynthetic gene cluster and enzymes related to central carbon metabolism, cell energy and redox balance. Thus this approach suggested new insights to improve fermentation technology strategies and revealed target genes for synthetic biology approaches aimed to improve antibiotic yield production.

UR - http://hdl.handle.net/10447/100840

M3 - Paper

ER -