Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

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Abstract

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.
Lingua originaleEnglish
pagine (da-a)288-293
Numero di pagine6
RivistaAnnals of the New York Academy of Sciences
Volume1067
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • History and Philosophy of Science
  • Biochemistry, Genetics and Molecular Biology(all)

Cita questo

@article{25028c1485de411aa867ae8a35ba0eac,
title = "Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis",
abstract = "The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.",
author = "Calogero Caruso and {Colonna Romano}, Giuseppina and Giuseppina Candore and Domenico Lio and Forte, {Giusi Irma} and Letizia Scola and Robertina Giacconi and Domenico Nuzzo and Antonino Crivello and Giacalone, {Antonio Mario} and Catia Cipriano and Robertina Giacconi and Eugenio Mocchegiani",
year = "2006",
language = "English",
volume = "1067",
pages = "288--293",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

AU - Caruso, Calogero

AU - Colonna Romano, Giuseppina

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Forte, Giusi Irma

AU - Scola, Letizia

AU - Giacconi, Robertina

AU - Nuzzo, Domenico

AU - Crivello, Antonino

AU - Giacalone, Antonio Mario

AU - Cipriano, Catia

AU - Giacconi, Robertina

AU - Mocchegiani, Eugenio

PY - 2006

Y1 - 2006

N2 - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

AB - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

UR - http://hdl.handle.net/10447/31318

M3 - Article

VL - 1067

SP - 288

EP - 293

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -