Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Domenico Lio; Giusi Irma Forte; Letizia Scola; Giuseppina Candore; Calogero Caruso; Giuseppina Colonna Romano; Catia Cipriano; Robertina Giacconi; Eugenio Mocchegiani; Antonino Crivello; Antonio Mario Giacalone; Domenico Nuzzo; Robertina Giacconi

Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Domenico Lio, Giusi Irma Forte, Letizia Scola, Giuseppina Candore, Calogero Caruso, Giuseppina Colonna Romano, Catia Cipriano, Robertina Giacconi, Eugenio Mocchegiani, Antonino Crivello, Antonio Mario Giacalone, Domenico Nuzzo, Robertina Giacconi

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Article › peer review

7 Citazioni (Scopus)

Abstract

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

Lingua originale	English
pagine (da-a)	288-293
Numero di pagine	6
Rivista	Annals of the New York Academy of Sciences
Volume	1067
Stato di pubblicazione	Published - 2006

All Science Journal Classification (ASJC) codes

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Lio, D., Forte, G. I., Scola, L., Candore, G., Caruso, C., Colonna Romano, G., Cipriano, C., Giacconi, R., Mocchegiani, E., Crivello, A., Giacalone, A. M., Nuzzo, D., & Giacconi, R. (2006). Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. Annals of the New York Academy of Sciences, 1067, 288-293.

Lio, D , Forte, GI , Scola, L , Candore, G , Caruso, C , Colonna Romano, G, Cipriano, C, Giacconi, R, Mocchegiani, E, Crivello, A, Giacalone, AM, Nuzzo, D & Giacconi, R 2006, 'Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis', Annals of the New York Academy of Sciences, vol. 1067, pagg. 288-293.

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title = "Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis",

abstract = "The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.",

author = "Domenico Lio and Forte, {Giusi Irma} and Letizia Scola and Giuseppina Candore and Calogero Caruso and {Colonna Romano}, Giuseppina and Catia Cipriano and Robertina Giacconi and Eugenio Mocchegiani and Antonino Crivello and Giacalone, {Antonio Mario} and Domenico Nuzzo and Robertina Giacconi",

year = "2006",

language = "English",

volume = "1067",

pages = "288--293",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

AU - Lio, Domenico

AU - Forte, Giusi Irma

AU - Scola, Letizia

AU - Candore, Giuseppina

AU - Caruso, Calogero

AU - Colonna Romano, Giuseppina

AU - Cipriano, Catia

AU - Giacconi, Robertina

AU - Mocchegiani, Eugenio

AU - Crivello, Antonino

AU - Giacalone, Antonio Mario

AU - Nuzzo, Domenico

AU - Giacconi, Robertina

PY - 2006

Y1 - 2006

N2 - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

AB - The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.

UR - http://hdl.handle.net/10447/31318

M3 - Article

SN - 0077-8923

VL - 1067

SP - 288

EP - 293

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

Abstract

All Science Journal Classification (ASJC) codes

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