Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 79-85 |
| Numero di pagine | 7 |
| Rivista | Annals of the New York Academy of Sciences |
| Volume | 1270 |
| Stato di pubblicazione | Published - 2012 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- History and Philosophy of Science
- Biochemistry, Genetics and Molecular Biology(all)
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Fragments of -thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms. / Schillaci, Domenico; Arizza, Vincenzo; Cusimano, Maria Grazia; Vitale, Maria.
In: Annals of the New York Academy of Sciences, Vol. 1270, 2012, pag. 79-85.Risultato della ricerca: Article
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TY - JOUR
T1 - Fragments of -thymosin from the sea urchin Paracentrotus lividus as potential antimicrobial peptides against staphylococcal biofilms
AU - Schillaci, Domenico
AU - Arizza, Vincenzo
AU - Cusimano, Maria Grazia
AU - Vitale, Maria
PY - 2012
Y1 - 2012
N2 - The immune mediators in echinoderms can be a potential source of novel antimicrobial peptides (AMPs) applied toward controlling pathogenic staphylococcal biofilms that are intrinsically resistant to conventional antibiotics. The peptide fraction <5 kDa from the cytosol of coelomocytes of the sea urchin Paracentrotus lividus (5-CC) was tested against a group of Gram-positive and Gram-negative pathogen reference strains. The 5-CC of P. lividus was active against all planktonic-tested strains but also showed antibiofilm properties against staphylococcal strains. Additionally,wedemonstrated the presenceof three smallpeptides in the5-CCbelonging tosegment 9-41of aP. lividus -thymosin. The smallest of these peptides in particular, showed the common chemical–physical characteristics of AMPs. This novel AMP from -thymosin has high potential activity as an antibiofilm agent, acting on slow-growing bacterial cells that exhibit a reduced susceptibility to conventional antibiotics and represent a reservoir for recurrent biofilm-associated infections.
AB - The immune mediators in echinoderms can be a potential source of novel antimicrobial peptides (AMPs) applied toward controlling pathogenic staphylococcal biofilms that are intrinsically resistant to conventional antibiotics. The peptide fraction <5 kDa from the cytosol of coelomocytes of the sea urchin Paracentrotus lividus (5-CC) was tested against a group of Gram-positive and Gram-negative pathogen reference strains. The 5-CC of P. lividus was active against all planktonic-tested strains but also showed antibiofilm properties against staphylococcal strains. Additionally,wedemonstrated the presenceof three smallpeptides in the5-CCbelonging tosegment 9-41of aP. lividus -thymosin. The smallest of these peptides in particular, showed the common chemical–physical characteristics of AMPs. This novel AMP from -thymosin has high potential activity as an antibiofilm agent, acting on slow-growing bacterial cells that exhibit a reduced susceptibility to conventional antibiotics and represent a reservoir for recurrent biofilm-associated infections.
KW - antibiofilm agents; antimicrobial peptides (AMPs); staphylococcal biofilms
UR - http://hdl.handle.net/10447/78373
M3 - Article
VL - 1270
SP - 79
EP - 85
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -