FOKI AND BSMI VITAMIN D RECEPTOR GENE POLYMORPHISMS, PLASMA RENIN ACTIVITY AND ESSENTIAL ARTERIAL HYPERTENSION

Risultato della ricerca: Other

Abstract

Objective: Our aims were to analyze the relationship between 25hydroxyvitaminD(25[OH]D) plasma levels and clinical and ambulatory blood pressure (BP) values,and to identify any possible association between hypertension and FokI and BsmIvitamin D receptor (VDR) gene polymorphisms in essential hypertensive patients.Design and method: Seventyoneessential hypertensive patients and seventytwocontrols, 18–75 years old, were enrolled. Clinical physical examination, routineblood chemistry, clinical BP, 24 hour ambulatory blood pressure monitoring,25[OH]D and Plasma Renin Activity (PRA) assay, and FokI and BsmI VDRpolymorphisms analysis were obtained.Results:We observed a significant negative correlation between 25[OH]D and 24 hsystolic BP (r = 0.277,p = 0.043) (Figure 1).This correlation persisted in backward stepwise multivariate analyses (b=0.337;p = 0.022) including as covariates first age, gender, body mass index, glomerular filtrationrate estimated (eGFR) by MDRD equation, and secondly PRA. Furthermorebody mass index (b=0.290; p = 0.037) and eGFRMDRD(b=0.301;p = 0.038)were independently correlated to 24 h systolic BP. We did not observe statisticallysignificant correlation between 25[OH]D and PRA.When we compared anthropometric, clinical and biohumoralparameters amongpatients with different VDR (FokI and BsmI) genotypes, we found a significant differenceof clinic diastolic BP values among the three FokI genotypes (p = 0.018).Significantly higher diastolic BP values in patients with ff FokI genotype comparedwith patients with Ff FokI genotype (p = 0.002) were disclosed through the MannWhitneyU test.Lastly any association between a specific genotype or allele and hypertension orPRAwas not found when we compared allelic frequencies and genotype distributionbetween patients and controls.Conclusions: Our findings confirm the relation between 25[OH]D and BP valuesin essential hypertensive patients and they suggest that FokI and BmsI VDRpolymorphisms is not associated either with hypertension or with PRA.
Lingua originaleEnglish
Pagine510-510
Numero di pagine1
Stato di pubblicazionePublished - 2015

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