Focusing on Ciona intestinalis (Tunicata) innate immune system. Evolutionary implications

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Abstract

Phylogenetic analyses based on molecular data provide compelling evidence that ascidians are ofcritical importance for studying chordate immune system evolution. The Ciona intestinalis draftgenome sequence allows searches for phylogenetic relationships, gene cloning and expression ofimmunorelevant molecules. Acidians lack of the pivotal components of the vertebrate recombinatoryadaptive immunity, i.e., MHC, TCRs and dimeric immunoglobulins. However, bioinformatic sequenceanalyses recognized genic elements indicating the essential features of the Ig superfamily andancestor proto-MHC genes, suggesting a primitive pre-duplication and pre-recombination status. C.intestinalis genes for individuality in the absence of MHC could encode diverse molecular markers,including a wide panel of complement factors that could be responsible for self-nonself discrimination.Genome analysis reveals a number of innate immunity vertebrate-like genes which encode Toll-likeand virus receptors, complement pathways components and receptors, CD94/NK-receptor-like, lectins,TNF, IL1-R, collagens. However, pure homology seeking for vertebrate-specific immunorelevantmolecules is of limited value, and functional screening methods may be a more promising approach fortracing the immune system evolution. C. intestinalis, which displays acute and chronic inflammatoryreactions, is a model organism for studying innate immunity genes expression and functions.
Lingua originaleEnglish
Numero di pagine0
RivistaInvertebrate Survival Journal
Volume2009-03
Stato di pubblicazionePublished - 2009

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Tunicata
vertebrates
immune system
complement
gene expression
receptors
Chordata
genes
phylogeny
Ascidiacea
bioinformatics
lectins
immunoglobulins
collagen
molecular cloning
immunity
screening
genetic markers
genome
organisms

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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title = "Focusing on Ciona intestinalis (Tunicata) innate immune system. Evolutionary implications",
abstract = "Phylogenetic analyses based on molecular data provide compelling evidence that ascidians are ofcritical importance for studying chordate immune system evolution. The Ciona intestinalis draftgenome sequence allows searches for phylogenetic relationships, gene cloning and expression ofimmunorelevant molecules. Acidians lack of the pivotal components of the vertebrate recombinatoryadaptive immunity, i.e., MHC, TCRs and dimeric immunoglobulins. However, bioinformatic sequenceanalyses recognized genic elements indicating the essential features of the Ig superfamily andancestor proto-MHC genes, suggesting a primitive pre-duplication and pre-recombination status. C.intestinalis genes for individuality in the absence of MHC could encode diverse molecular markers,including a wide panel of complement factors that could be responsible for self-nonself discrimination.Genome analysis reveals a number of innate immunity vertebrate-like genes which encode Toll-likeand virus receptors, complement pathways components and receptors, CD94/NK-receptor-like, lectins,TNF, IL1-R, collagens. However, pure homology seeking for vertebrate-specific immunorelevantmolecules is of limited value, and functional screening methods may be a more promising approach fortracing the immune system evolution. C. intestinalis, which displays acute and chronic inflammatoryreactions, is a model organism for studying innate immunity genes expression and functions.",
keywords = "Ciona intestinalis, immunity",
author = "Nicolo' Parrinello",
year = "2009",
language = "English",
volume = "2009-03",
journal = "Invertebrate Survival Journal",
issn = "1824-307X",
publisher = "University of Modena and Reggio Emilia",

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AU - Parrinello, Nicolo'

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N2 - Phylogenetic analyses based on molecular data provide compelling evidence that ascidians are ofcritical importance for studying chordate immune system evolution. The Ciona intestinalis draftgenome sequence allows searches for phylogenetic relationships, gene cloning and expression ofimmunorelevant molecules. Acidians lack of the pivotal components of the vertebrate recombinatoryadaptive immunity, i.e., MHC, TCRs and dimeric immunoglobulins. However, bioinformatic sequenceanalyses recognized genic elements indicating the essential features of the Ig superfamily andancestor proto-MHC genes, suggesting a primitive pre-duplication and pre-recombination status. C.intestinalis genes for individuality in the absence of MHC could encode diverse molecular markers,including a wide panel of complement factors that could be responsible for self-nonself discrimination.Genome analysis reveals a number of innate immunity vertebrate-like genes which encode Toll-likeand virus receptors, complement pathways components and receptors, CD94/NK-receptor-like, lectins,TNF, IL1-R, collagens. However, pure homology seeking for vertebrate-specific immunorelevantmolecules is of limited value, and functional screening methods may be a more promising approach fortracing the immune system evolution. C. intestinalis, which displays acute and chronic inflammatoryreactions, is a model organism for studying innate immunity genes expression and functions.

AB - Phylogenetic analyses based on molecular data provide compelling evidence that ascidians are ofcritical importance for studying chordate immune system evolution. The Ciona intestinalis draftgenome sequence allows searches for phylogenetic relationships, gene cloning and expression ofimmunorelevant molecules. Acidians lack of the pivotal components of the vertebrate recombinatoryadaptive immunity, i.e., MHC, TCRs and dimeric immunoglobulins. However, bioinformatic sequenceanalyses recognized genic elements indicating the essential features of the Ig superfamily andancestor proto-MHC genes, suggesting a primitive pre-duplication and pre-recombination status. C.intestinalis genes for individuality in the absence of MHC could encode diverse molecular markers,including a wide panel of complement factors that could be responsible for self-nonself discrimination.Genome analysis reveals a number of innate immunity vertebrate-like genes which encode Toll-likeand virus receptors, complement pathways components and receptors, CD94/NK-receptor-like, lectins,TNF, IL1-R, collagens. However, pure homology seeking for vertebrate-specific immunorelevantmolecules is of limited value, and functional screening methods may be a more promising approach fortracing the immune system evolution. C. intestinalis, which displays acute and chronic inflammatoryreactions, is a model organism for studying innate immunity genes expression and functions.

KW - Ciona intestinalis

KW - immunity

UR - http://hdl.handle.net/10447/35087

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VL - 2009-03

JO - Invertebrate Survival Journal

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SN - 1824-307X

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