Focal liver lesions: clinical usefulness of contrast-enhanced ultrasound in the selection of surgical patients

Mario Latteri, Tommaso Vincenzo Bartolotta, Maurizio Soresi, Adele Taibbi, Giuseppina Lombardo, Luigi Sandonato, Stefania Latteri

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)


Purpose: to evaluate the role of contrast-enhanced ultrasound (CEUS) in the characterization of focal liver lesions (FLLs) for surgical patients selection.Materials and Methods: 135 consecutive patients (71 women, 64 men) with 165 FLLs (mean size: 3.1 cm) - 89 benign (10 simple cysts, 26 hemangiomas, 29 focal nodular hyperplasia (FNH), 2 hepatocellular adenomas, 11 focal fatty sparing, 3 focal fatty areas, 5 regenerative nodules, 2 hydatid cysts, 1 abscess) and 76 malignant - 47 metastases, 26 hepatocellular carcinomas and 3 peripheral cholangiocarcinomas - underwent CEUS after the administration of SonoVue®. Two readers reviewed in consensus baseline US and CEUS scans obtained 25-30 s (arterial phase), 55-80 s (portal-venous phase), and 235-260 s (late phase) after the beginning of SonoVue® injection respectively. The readers classified each lesion as malignant or benign by means of definite diagnostic criteria. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were calculated.Results: CEUS correctly ha characterized 156/165 (94,5%) FLLs, 85 benign and 71 malignant. 5/165 (3%) FLLs, 3 hemangiomas e 2 HCCs, remained undetermined after CEUS and 4/165 (2,4%) FLLs, 3 HCCs and 1 abscess were misdiagnosed. CEUS showed sensitivity, specificity, and diagnostic accuracy values of 93,4%, 95,5% e 94,7% respectively. positive predictive value and negative predictive values were 94,7% e 94,4%.
Lingua originaleItalian
pagine (da-a)295-307
Numero di pagine13
RivistaChirurgia Italiana
Stato di pubblicazionePublished - 2009

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