First case in Italy of acquired resistance to oseltamivir in an immunocompromised patient with influenza A/H1N1v infection

Fabio Tramuto, Marzia Facchini, Giulia Campanini, Antonio Piralla, Francesca Rovida, Simona Puzelli, Francesca Rovida, Isabella Donatelli, Elena Percivalle, Lorenzo Minoli, Fausto Baldanti, Franco Locatelli

Risultato della ricerca: Articlepeer review

25 Citazioni (Scopus)

Abstract

A pandemic influenza A/H1N1v strain with the neuraminidase H274Y mutation was detected in nasal secretions of a 2-year-old leukemic patient with influenza-like illness after 18 days of treatment with oseltamivir. At baseline, no drug-resistant virus was found, while 4 days after treatment initiation a mix- ture of wild-type and mutated virus was detected. After treatment interruption, the wild type influenza virus re-emerged and became prevalent in nasal secretions after a few days, suggesting the lower fitness of the mutated virus strain. The patient slowly improved concurrently with a decrease in virus load, which resulted negative 42 days after diagnosis. No other drug-resistant influenza A/H1N1v virus strains have been detected in Italy (up to the end of November 2009) since the first case of the novel A/H1N1v virus was identified in the country (May 2009).
Lingua originaleEnglish
pagine (da-a)220-222
Numero di pagine3
RivistaJOURNAL OF CLINICAL VIROLOGY
Volume48
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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