Fibrous hamartoma of Infancy: An Italian multi-istitutional experience.

Fibrous hamartoma of infancy: an Italian multi-institutional experience.Carretto E, Dall'Igna P, Alaggio R, Siracusa F, Granata C, Ferrari A, Cecchetto G.SourceDivision of Paediatric Surgery, Department of Paediatrics, University of Padua, Padua, Italy.AbstractBACKGROUND:Fibrous hamartoma (FH) of infancy is a benign mesenchymal tumor, occurring as a superficial mass. Complete excision is curative.OBJECTIVE AND METHODS:The clinical features and treatment results of 18 children with FH are described.RESULTS:Local excision was the most common procedure. Surgery was radical in 10 patients, with microscopic residual disease in 6; all of them are alive with no evidence of disease 2 to 49 months after diagnosis. One patient, treated with a local reexcision for macroscopic residual disease (and chemotherapy for a synchronous desmoid fibromatosis) is well 83 months after diagnosis; the last patient, with a lesion of the labia majora, only underwent biopsy and is doing well, awaiting plastic surgery.LIMITATIONS:The results did not reach statistical significance due to difficulties in collecting cases.CONCLUSIONS:FH should be treated by complete excision; in our experience a nonradical excision was also able to achieve the cure. An aggressive approach should be avoided, as the overall prognosis is excellent.PMID: 16635660 [PubMed - indexed for MEDLINE]