Fibronectin type III domain-containing protein 5 rs3480 A>G polymorphism, irisin, and liver fibrosis in patients with Nonalcoholic fatty liver disease

Stefania Grimaudo, Daniela Cabibi, Salvatore Petta, Calogero Camma', Vito Di Marco, Antonio Craxi, Rosaria Maria Pipitone, Chiara Rychlicki, Irene Pierantonelli, Marica Meroni, Debora Giordano, Gianluca Svegliati-Baroni, Nicola Ferri, Luca Valenti, Massimiliano Ruscica, Paola Dongiovanni, Nicola Ferri, Anna Ludovica Fracanzani, Marco Maggioni, Luca ValentiSilvia Fargion

Risultato della ricerca: Articlepeer review

23 Citazioni (Scopus)

Abstract

Contrasting data have been reported on the role of irisin, a novel myokine encoded by the FNDC5 gene, in NAFLD pathogenesis. We tested in patients with suspected NASH the association of FNDC5 variants, hepatic expression and circulating irisin with liver damage(F2-F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models.
Lingua originaleEnglish
pagine (da-a)2660-2669
Numero di pagine10
RivistaTHE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Volume102
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1300.1310???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.2700.2704???

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