Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype

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Abstract

Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).
Lingua originaleEnglish
Titolo della pubblicazione ospiteMedical Biotechnologies and Forensic Medicine Review
Pagine53-58
Numero di pagine6
Stato di pubblicazionePublished - 2011

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