Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype

Bruna Lo Sasso; Antonietta Caruso; Marcello Ciaccio; Giulia Bivona; Patrizia Maiorana

Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype

Bruna Lo Sasso, Antonietta Caruso, Marcello Ciaccio, Giulia Bivona, Patrizia Maiorana

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Chapter

Abstract

Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).

Lingua originale	English
Titolo della pubblicazione ospite	Medical Biotechnologies and Forensic Medicine Review
Pagine	53-58
Numero di pagine	6
Stato di pubblicazione	Published - 2011

Altri file e collegamenti

OA Link

Fingerprint Entra nei temi di ricerca di 'Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype'. Insieme formano una fingerprint unica.

Cita questo

@inbook{0d00d064fbdc46eb963a52b9ad5bf381,

title = "Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype",

abstract = "Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).",

keywords = "End Stage Renal Disease, Fetuin- A, cardiovascular disease, inflammation, End Stage Renal Disease, Fetuin- A, cardiovascular disease, inflammation",

author = "{Lo Sasso}, Bruna and Antonietta Caruso and Marcello Ciaccio and Giulia Bivona and Patrizia Maiorana",

year = "2011",

language = "English",

pages = "53--58",

booktitle = "Medical Biotechnologies and Forensic Medicine Review",

}

TY - CHAP

T1 - Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype

AU - Lo Sasso, Bruna

AU - Caruso, Antonietta

AU - Ciaccio, Marcello

AU - Bivona, Giulia

AU - Maiorana, Patrizia

PY - 2011

Y1 - 2011

N2 - Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).

AB - Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).

KW - End Stage Renal Disease

KW - Fetuin- A

KW - cardiovascular disease

KW - inflammation

KW - End Stage Renal Disease

KW - Fetuin- A

KW - cardiovascular disease

KW - inflammation

UR - http://hdl.handle.net/10447/66228

M3 - Chapter

SP - 53

EP - 58

BT - Medical Biotechnologies and Forensic Medicine Review

ER -