Abstract
Several studies showed that Fetuin-a is an extracellular calcium-regulatory protein acting as a potent inhibitor of calcium-phosphate precipitation, involved also in bone metabolism because of its high affinity for hydroxyapatite. The aim of this study is to evaluate the serum Fetuin-A levels in patients with chronic renal failure before and after a single session of dialysis and to investigate the correlation between protein serum concentrations and T256S genotype. Our results show that serum Fetuin- A levels decrease 4 hours after haemodialysis treatment and a significant correlation between 256SS homozygote and serum protein levels. Ectopic calcification and particularly intravascular calcification is inhibited by Fetuin-A and this mechanism seems to be of some importance in cardiovascular morbidity and mortality in patients with End Stage Renal Disease (ESRD).
| Lingua originale | English |
|---|---|
| Titolo della pubblicazione ospite | Medical Biotechnologies and Forensic Medicine Review |
| Pagine | 53-58 |
| Numero di pagine | 6 |
| Stato di pubblicazione | Published - 2011 |
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Bivona, G., Ciaccio, M., Lo Sasso, B., Caruso, A., & Maiorana, P. (2011). Fetun-A and end stage renal disease: correlations with haemodialytic single session and genotype. In Medical Biotechnologies and Forensic Medicine Review (pagg. 53-58)