Fetuin-A serum levels are not correlated to kidney function in long-lived subjects

Marcello Ciaccio, Antonietta Caruso, Chiara Bellia, Bruna Lo Sasso, Federica Zarrilli, Rossella Tomaiuolo, Angelo Zinellu, Maria Deiana, Luca Deiana, Ciriaco Carru, Giuseppe Castaldo, Sara Pinna

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher prevalence of arterial calcification observed in these patients. During ageing both the stiffening of arterial wall due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin A serum levels are associated with ageing and with AHSG T256S polymorphism. Moreover, we aim at investigate whether serum Fetuin A is correlated to kidney function in this setting of senescence. Design and Methods: 256 health long-lived subjects (age 92 [81-100] were recruited for the study. Serum Fetuin A was evaluated by ELISA, Cystatin C by immune-nephelometry. AHSG T256S was determinated by PCR-RFLP. Results: Serum Fetuin A shows a significant correlation with age (r = 0.20; P = 0.0048). AHSG TS and SS genotypes are associated to lower levels of serum protein (0.27 [0.19-0.29] g/l vs 0.42 [0.32-0.49] g/l; P<0.027 and 0.34 [0.25-0.41] g/l vs 0.42 [0.32-0.49] g/l; P<0.001, respectively). No significant correlation between Fetuin A and Cystatin C was observed. Conclusions: Serum Fetuin A increases with age in elder individuals and subjects with the TS or SS AHSG polymorphism have lower levels of the circulating protein. No correlation with kidney function decline was observed. Other mechanisms should be investigated to explain the increase of Fetuin A with age.
Lingua originaleEnglish
pagine (da-a)637-640
Numero di pagine4
RivistaClinical Biochemistry
Volume45
Stato di pubblicazionePublished - 2012

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alpha-2-HS-Glycoprotein
Kidney
Serum
Cystatin C
Polymorphism
Chronic Renal Insufficiency
Aging of materials
Nephelometry and Turbidimetry
Restriction Fragment Length Polymorphisms
Blood Proteins
Enzyme-Linked Immunosorbent Assay
Genotype
Health
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cita questo

Fetuin-A serum levels are not correlated to kidney function in long-lived subjects. / Ciaccio, Marcello; Caruso, Antonietta; Bellia, Chiara; Lo Sasso, Bruna; Zarrilli, Federica; Tomaiuolo, Rossella; Zinellu, Angelo; Deiana, Maria; Deiana, Luca; Carru, Ciriaco; Castaldo, Giuseppe; Pinna, Sara.

In: Clinical Biochemistry, Vol. 45, 2012, pag. 637-640.

Risultato della ricerca: Article

Ciaccio, M, Caruso, A, Bellia, C, Lo Sasso, B, Zarrilli, F, Tomaiuolo, R, Zinellu, A, Deiana, M, Deiana, L, Carru, C, Castaldo, G & Pinna, S 2012, 'Fetuin-A serum levels are not correlated to kidney function in long-lived subjects', Clinical Biochemistry, vol. 45, pagg. 637-640.
Ciaccio, Marcello ; Caruso, Antonietta ; Bellia, Chiara ; Lo Sasso, Bruna ; Zarrilli, Federica ; Tomaiuolo, Rossella ; Zinellu, Angelo ; Deiana, Maria ; Deiana, Luca ; Carru, Ciriaco ; Castaldo, Giuseppe ; Pinna, Sara. / Fetuin-A serum levels are not correlated to kidney function in long-lived subjects. In: Clinical Biochemistry. 2012 ; Vol. 45. pagg. 637-640.
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title = "Fetuin-A serum levels are not correlated to kidney function in long-lived subjects",
abstract = "Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher prevalence of arterial calcification observed in these patients. During ageing both the stiffening of arterial wall due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin A serum levels are associated with ageing and with AHSG T256S polymorphism. Moreover, we aim at investigate whether serum Fetuin A is correlated to kidney function in this setting of senescence. Design and Methods: 256 health long-lived subjects (age 92 [81-100] were recruited for the study. Serum Fetuin A was evaluated by ELISA, Cystatin C by immune-nephelometry. AHSG T256S was determinated by PCR-RFLP. Results: Serum Fetuin A shows a significant correlation with age (r = 0.20; P = 0.0048). AHSG TS and SS genotypes are associated to lower levels of serum protein (0.27 [0.19-0.29] g/l vs 0.42 [0.32-0.49] g/l; P<0.027 and 0.34 [0.25-0.41] g/l vs 0.42 [0.32-0.49] g/l; P<0.001, respectively). No significant correlation between Fetuin A and Cystatin C was observed. Conclusions: Serum Fetuin A increases with age in elder individuals and subjects with the TS or SS AHSG polymorphism have lower levels of the circulating protein. No correlation with kidney function decline was observed. Other mechanisms should be investigated to explain the increase of Fetuin A with age.",
keywords = "Fetuin A, Cystatin C, elderly, kidney disease, AHSG",
author = "Marcello Ciaccio and Antonietta Caruso and Chiara Bellia and {Lo Sasso}, Bruna and Federica Zarrilli and Rossella Tomaiuolo and Angelo Zinellu and Maria Deiana and Luca Deiana and Ciriaco Carru and Giuseppe Castaldo and Sara Pinna",
year = "2012",
language = "English",
volume = "45",
pages = "637--640",
journal = "Clinical Biochemistry",
issn = "0009-9120",
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TY - JOUR

T1 - Fetuin-A serum levels are not correlated to kidney function in long-lived subjects

AU - Ciaccio, Marcello

AU - Caruso, Antonietta

AU - Bellia, Chiara

AU - Lo Sasso, Bruna

AU - Zarrilli, Federica

AU - Tomaiuolo, Rossella

AU - Zinellu, Angelo

AU - Deiana, Maria

AU - Deiana, Luca

AU - Carru, Ciriaco

AU - Castaldo, Giuseppe

AU - Pinna, Sara

PY - 2012

Y1 - 2012

N2 - Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher prevalence of arterial calcification observed in these patients. During ageing both the stiffening of arterial wall due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin A serum levels are associated with ageing and with AHSG T256S polymorphism. Moreover, we aim at investigate whether serum Fetuin A is correlated to kidney function in this setting of senescence. Design and Methods: 256 health long-lived subjects (age 92 [81-100] were recruited for the study. Serum Fetuin A was evaluated by ELISA, Cystatin C by immune-nephelometry. AHSG T256S was determinated by PCR-RFLP. Results: Serum Fetuin A shows a significant correlation with age (r = 0.20; P = 0.0048). AHSG TS and SS genotypes are associated to lower levels of serum protein (0.27 [0.19-0.29] g/l vs 0.42 [0.32-0.49] g/l; P<0.027 and 0.34 [0.25-0.41] g/l vs 0.42 [0.32-0.49] g/l; P<0.001, respectively). No significant correlation between Fetuin A and Cystatin C was observed. Conclusions: Serum Fetuin A increases with age in elder individuals and subjects with the TS or SS AHSG polymorphism have lower levels of the circulating protein. No correlation with kidney function decline was observed. Other mechanisms should be investigated to explain the increase of Fetuin A with age.

AB - Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher prevalence of arterial calcification observed in these patients. During ageing both the stiffening of arterial wall due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin A serum levels are associated with ageing and with AHSG T256S polymorphism. Moreover, we aim at investigate whether serum Fetuin A is correlated to kidney function in this setting of senescence. Design and Methods: 256 health long-lived subjects (age 92 [81-100] were recruited for the study. Serum Fetuin A was evaluated by ELISA, Cystatin C by immune-nephelometry. AHSG T256S was determinated by PCR-RFLP. Results: Serum Fetuin A shows a significant correlation with age (r = 0.20; P = 0.0048). AHSG TS and SS genotypes are associated to lower levels of serum protein (0.27 [0.19-0.29] g/l vs 0.42 [0.32-0.49] g/l; P<0.027 and 0.34 [0.25-0.41] g/l vs 0.42 [0.32-0.49] g/l; P<0.001, respectively). No significant correlation between Fetuin A and Cystatin C was observed. Conclusions: Serum Fetuin A increases with age in elder individuals and subjects with the TS or SS AHSG polymorphism have lower levels of the circulating protein. No correlation with kidney function decline was observed. Other mechanisms should be investigated to explain the increase of Fetuin A with age.

KW - Fetuin A, Cystatin C, elderly, kidney disease, AHSG

UR - http://hdl.handle.net/10447/64103

M3 - Article

VL - 45

SP - 637

EP - 640

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

ER -