FERULIC ACID INHIBITS OXIDATE STRESS AND CELL DEATH INDUCED BY Ab OLIGOMERS: IMPROVED DELIVERY BY SOLID LIPID NANOPARTICLES.

Giovanna Pitarresi, Gaetano Giammona, Pasquale Picone, Maria L. Bondi, Giovanna Montana, Marta Di Carlo, Andreina Bruno, Pasquale Picone

Risultato della ricerca: Articlepeer review

87 Citazioni (Scopus)

Abstract

Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering neurodegeneration. The useof natural antioxidants could be a neuroprotective strategy for blocking cell death. Here, the antioxidant action of ferulic acid(FA) on different paths leading to degeneration of recombinant b-amyloid peptide (rAb42) treated cells was investigated.Further, to improve its delivery, a novel drug delivery system (DDS) was used. Solid lipid nanoparticles (SLNs), empty orcontaining ferulic acid (FA-SNL), were developed as DDS. The resulting particles had small colloidal size and highlynegative surface charge in water. Using neuroblastoma cells and rAb42 oligomers, it was demonstrated that free and SLNsloadedFA recover cell viability. FA treatment, in particular if loaded into SLNs, decreased ROS generation, restoredmitochondrial membrane potential (Dcm) and reduced cytochrome c release and intrinsic pathway apoptosis activation.Further, FA modulated the expression of Peroxiredoxin, an anti-oxidative protein, and attenuated phosphorylation of ERK1/2 activated by Ab oligomers.
Lingua originaleEnglish
pagine (da-a)1133-1145
Numero di pagine13
RivistaFree Radical Research
Volume43
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry

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