Fertility-sparing approach in women affected by stage i and low-grade endometrial carcinoma: An updated overview

Antonino Perino, Vito Chiantera, Antonio Simone Laganà, Marco Noventa, Pierluigi Giampaolino, Antonio Simone Laganà, Amerigo Vitagliano, Giovanni Buzzaccarini, Rossella Tomaiuolo, Alessandra Andrisani, Alessia Vitagliano, Andrea Etrusco, Giuseppe Cucinella, Giuseppe Gullo

Risultato della ricerca: Articlepeer review

34 Citazioni (Scopus)


Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.
Lingua originaleEnglish
Numero di pagine12
RivistaInternational Journal of Molecular Sciences
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.1600.1607???
  • ???subjectarea.asjc.1700.1706???
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