TY - JOUR
T1 - FENTANYL AND SUFENTANYL IN FAST TRACK ANAESTHESIA FOR MAJOR INTRA-ABDOMINAL SURGERY
AU - Damiani, Francesco
AU - Buscemi, Giuseppe
AU - Tomasello, Giovanni
AU - Lo Monte, Attilio Ignazio
AU - Gioviale, Maria Concetta
AU - Palumbo, Vincenzo Davide
AU - Damiano, Giuseppe
AU - Damiani, Francesco
AU - Buscemi, Giuseppe
PY - 2012
Y1 - 2012
N2 - Background and aim: Major intra-abdominal surgery is estimated to have high costs annually in Italy. In an attempt todecrease surgery costs and improve outcome for patients, fast-track programs have become popular. This is especially due both to theimprovement of surgery and to the new anesthetic agents (regarding pharmacokinetic and pharmacodynamic) resulting in better carefor patients. The aim of this study was to evaluate two different anesthetic protocols in patients undergoing scheduled anesthesiaincluding the combination of two different opioids (fentanyl or sufentanil) with the same hypnotic and muscle relaxant.Material and Methods: 40 patients, with an American Society of Anesthesiology score (ASA) 3-4 undergoing surgery, wererandomly divided in two equal groups. Group F (fentanyl) received 7-10 mcg/kg and propofol, midazolam and cis-atracurium. GroupS (sufentanil) received propofol, midazolam, cis-atracurium and sufentanil 1,5-2 mcg/kg.Results: we measured post-operative pain, median ventilation time, time in intensive care unit (ICU) stay, time to hospital discharge,hemodynamics data and overall safety and satisfaction by the patients.Conclusions: our results suggest that both fentanyl and sufentanil can be recommended for fast-track anesthesia. Sufentanil,because of its pharmacokinetics and pharmacodynamics aspects, produce equally rapid extubation, similar stays and similar costswhen compared to fentanyl and can be recommended for fast track anesthesia.
AB - Background and aim: Major intra-abdominal surgery is estimated to have high costs annually in Italy. In an attempt todecrease surgery costs and improve outcome for patients, fast-track programs have become popular. This is especially due both to theimprovement of surgery and to the new anesthetic agents (regarding pharmacokinetic and pharmacodynamic) resulting in better carefor patients. The aim of this study was to evaluate two different anesthetic protocols in patients undergoing scheduled anesthesiaincluding the combination of two different opioids (fentanyl or sufentanil) with the same hypnotic and muscle relaxant.Material and Methods: 40 patients, with an American Society of Anesthesiology score (ASA) 3-4 undergoing surgery, wererandomly divided in two equal groups. Group F (fentanyl) received 7-10 mcg/kg and propofol, midazolam and cis-atracurium. GroupS (sufentanil) received propofol, midazolam, cis-atracurium and sufentanil 1,5-2 mcg/kg.Results: we measured post-operative pain, median ventilation time, time in intensive care unit (ICU) stay, time to hospital discharge,hemodynamics data and overall safety and satisfaction by the patients.Conclusions: our results suggest that both fentanyl and sufentanil can be recommended for fast-track anesthesia. Sufentanil,because of its pharmacokinetics and pharmacodynamics aspects, produce equally rapid extubation, similar stays and similar costswhen compared to fentanyl and can be recommended for fast track anesthesia.
UR - http://hdl.handle.net/10447/67827
M3 - Article
VL - 28
SP - 271
EP - 275
JO - Acta Medica Mediterranea
JF - Acta Medica Mediterranea
SN - 0393-6384
ER -