Features in tubercular meningoencephalitis diagnosis: 18 childhood cases

Alessandra Casuccio, Paola Di Carlo, Mazzola, Amelia Romano

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2 Citazioni (Scopus)

Abstract

The aim of this research is to illustrate clinical and instrumental features of central nervous system tuberculosis (CNS-TB) in childhood in order to allow prompt diagnosis and adequate patient management. TB remains one of the most important communicable diseases and represents a major global health problem. Although pulmonary TB tends to be the most common form of the disease, the highest mortality and morbidity occurs with TB of the central nervous system (CNS-TB), which develops in 4% of children with tuberculosis. It has a high fatality rate and causes serious sequelae, especially during childhood. CT and MR imaging studies of 18 patients (11 female, 7 male, mean age 45.72 months) were retrospectively reviewed. A basilar enhancement was detected in all the patients. Other findings were hydrocephalus (61%), intracranial tuberculomas (17%) other nodular (11%) and ischemic lesions (11%). Edema, either perilesional or diffuse, was found in 7/18 patients. Severe ventricular dilatation was observed in 9/18 cases. Two patients with fatal outcome had severe hydrocephalus associated with extensive ischemic areas in one case and intraventricular haemorrhage in the other. Cross-sectional imaging, together with clinical data, may provide useful clues for the early diagnosis of CNS-TB and help to prevent unnecessary morbidity and mortality.
Lingua originaleEnglish
pagine (da-a)187-192
Numero di pagine6
RivistaAmerican Journal of Infectious Diseases
Volume4
Stato di pubblicazionePublished - 2008

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Meningoencephalitis
Tuberculosis
Intracranial Tuberculoma
Morbidity
Fatal Outcome
Mortality
Hydrocephalus
Communicable Diseases
Dilatation
Edema
Central Nervous System
Lung
Health
Research

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

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title = "Features in tubercular meningoencephalitis diagnosis: 18 childhood cases",
abstract = "The aim of this research is to illustrate clinical and instrumental features of central nervous system tuberculosis (CNS-TB) in childhood in order to allow prompt diagnosis and adequate patient management. TB remains one of the most important communicable diseases and represents a major global health problem. Although pulmonary TB tends to be the most common form of the disease, the highest mortality and morbidity occurs with TB of the central nervous system (CNS-TB), which develops in 4{\%} of children with tuberculosis. It has a high fatality rate and causes serious sequelae, especially during childhood. CT and MR imaging studies of 18 patients (11 female, 7 male, mean age 45.72 months) were retrospectively reviewed. A basilar enhancement was detected in all the patients. Other findings were hydrocephalus (61{\%}), intracranial tuberculomas (17{\%}) other nodular (11{\%}) and ischemic lesions (11{\%}). Edema, either perilesional or diffuse, was found in 7/18 patients. Severe ventricular dilatation was observed in 9/18 cases. Two patients with fatal outcome had severe hydrocephalus associated with extensive ischemic areas in one case and intraventricular haemorrhage in the other. Cross-sectional imaging, together with clinical data, may provide useful clues for the early diagnosis of CNS-TB and help to prevent unnecessary morbidity and mortality.",
keywords = "Tuberculous meningitis, children, imaging",
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T1 - Features in tubercular meningoencephalitis diagnosis: 18 childhood cases

AU - Casuccio, Alessandra

AU - Di Carlo, Paola

AU - Mazzola, null

AU - Romano, Amelia

PY - 2008

Y1 - 2008

N2 - The aim of this research is to illustrate clinical and instrumental features of central nervous system tuberculosis (CNS-TB) in childhood in order to allow prompt diagnosis and adequate patient management. TB remains one of the most important communicable diseases and represents a major global health problem. Although pulmonary TB tends to be the most common form of the disease, the highest mortality and morbidity occurs with TB of the central nervous system (CNS-TB), which develops in 4% of children with tuberculosis. It has a high fatality rate and causes serious sequelae, especially during childhood. CT and MR imaging studies of 18 patients (11 female, 7 male, mean age 45.72 months) were retrospectively reviewed. A basilar enhancement was detected in all the patients. Other findings were hydrocephalus (61%), intracranial tuberculomas (17%) other nodular (11%) and ischemic lesions (11%). Edema, either perilesional or diffuse, was found in 7/18 patients. Severe ventricular dilatation was observed in 9/18 cases. Two patients with fatal outcome had severe hydrocephalus associated with extensive ischemic areas in one case and intraventricular haemorrhage in the other. Cross-sectional imaging, together with clinical data, may provide useful clues for the early diagnosis of CNS-TB and help to prevent unnecessary morbidity and mortality.

AB - The aim of this research is to illustrate clinical and instrumental features of central nervous system tuberculosis (CNS-TB) in childhood in order to allow prompt diagnosis and adequate patient management. TB remains one of the most important communicable diseases and represents a major global health problem. Although pulmonary TB tends to be the most common form of the disease, the highest mortality and morbidity occurs with TB of the central nervous system (CNS-TB), which develops in 4% of children with tuberculosis. It has a high fatality rate and causes serious sequelae, especially during childhood. CT and MR imaging studies of 18 patients (11 female, 7 male, mean age 45.72 months) were retrospectively reviewed. A basilar enhancement was detected in all the patients. Other findings were hydrocephalus (61%), intracranial tuberculomas (17%) other nodular (11%) and ischemic lesions (11%). Edema, either perilesional or diffuse, was found in 7/18 patients. Severe ventricular dilatation was observed in 9/18 cases. Two patients with fatal outcome had severe hydrocephalus associated with extensive ischemic areas in one case and intraventricular haemorrhage in the other. Cross-sectional imaging, together with clinical data, may provide useful clues for the early diagnosis of CNS-TB and help to prevent unnecessary morbidity and mortality.

KW - Tuberculous meningitis, children, imaging

UR - http://hdl.handle.net/10447/37933

M3 - Article

VL - 4

SP - 187

EP - 192

JO - American Journal of Infectious Diseases

JF - American Journal of Infectious Diseases

SN - 1553-6203

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