Factors involved in gastrointestinal bleeding in advanced cancer patients followed at home

Alessandra Casuccio, Fabio Fulfaro, Sebastiano Mercadante, Alessandro Valle, Stefania Silvestro, Flavio Fusco, Emanuela Donelli, Ferdinando Fusco

Risultato della ricerca: Articlepeer review

7 Citazioni (Scopus)


Abstract There is a lack of informationon the frequency of symptomaticgastrointestinal bleeding inpatients with advanced cancer. Thisgroup of patients presents several riskfactors for developing gastrointestinalbleeding. The aim of this multicenterlongitudinal survey was to assess thefrequency of gastrointestinal bleedingand possible factors implicated inadvanced cancer patients followed athome. A consecutive sample of 439patients who referred to home palliativecare program entered thestudy. Age, gender, primary cancerand known metastases, possible associatedpathologies, history of pepticdisease, use of previous or actualnonsteroidal anti-inflammatory drugs(NSAIDs) and steroids, drugs used toprevent gastric complications, theoccurrence of hematemesis or melena,significant anemia requiringblood transfusion, and mortality associatedwith the hemorrhagic eventwere recorded. Of 377 patients who completed the study, 18 reportedgastrointestinal bleeding, and fivehad significant anemia requiringblood transfusion in three cases.Death was found to be related tobleeding in three patients. NSAIDs,steroids, and gastroprotectors werefrequently used, either before orduring home care. However, no clearrelationship between age, gender, andthe use of offender drugs with gastrointestinalbleeding was found.Liver involvement was frequentlyassociated with the risk of developinggastrointestinal bleeding.
Lingua originaleEnglish
pagine (da-a)95-98
Numero di pagine4
RivistaSupportive Care in Cancer
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

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