Factors influencing psychological well-being in patients with Parkinson's disease

Marco D'Amelio, Pietro Cortelli, Giovanni Mostile, Claudio Pacchetti, Gianni Pezzoli, Margherita Canesi, Maria F. De Pandis, Claudio Pacchetti, Mario Zappia, Alessandra Nicoletti, Gianni Pezzoli, Fabrizio Stocchi, Giovanni Fabbrini, Roberto Ceravolo, Giovanni Abbruzzese, Alessandro Tessitore

Risultato della ricerca: Articlepeer review

22 Citazioni (Scopus)


BACKGROUND: Both motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale. OBJECTIVES: To evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates. METHODS: This article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional studyconducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL. RESULTS: 272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson's Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores. CONCLUSIONS: Non-motor symptoms have a significant impact on psychological well-being in PD patients.
Lingua originaleEnglish
Numero di pagine8
RivistaPLoS One
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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