Extracellular vesicles in airway homeostasis and pathophysiology

Francesco Cappello, Alessandro Pitruzzella, Fabio Bucchieri, Alberto Giuseppe Fucarino, Stefano Burgio, Domenico Michele Modica, Maria Concetta Zarcone, Fabio Bucchieri, Francesco Cappello, Domenico Michele Modica

Risultato della ricerca: Review articlepeer review

Abstract

The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here.
Lingua originaleEnglish
Numero di pagine11
RivistaAPPLIED SCIENCES
Volume11
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3100.3105???
  • ???subjectarea.asjc.2200.2200???
  • ???subjectarea.asjc.1500.1508???
  • ???subjectarea.asjc.1700.1706???
  • ???subjectarea.asjc.1500.1507???

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