Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

Pablo Reclusa Asiain, Simona Fontana, Marzia Pucci, Francesco Passiglia, Simona Taverna, Simona Taverna, Eloisa Jantus-Lewintre, Aung Naing, Shahanavaj Khan, Marzia Pucci, Elena Duréndez Sáez, Mahafarin Malarani, Pablo Reclusa Asiáin, Christian Rolfo, Luis E. Raez

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.
Lingua originaleEnglish
Numero di pagine13
RivistaTargeted Oncology
Stato di pubblicazionePublished - 2018

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MicroRNAs
Neoplasms
Extracellular Vesicles
Cellular Microenvironment
Tumor Microenvironment
Extracellular Space
Endothelial Cells
Fibroblasts
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression. / Reclusa Asiain, Pablo; Fontana, Simona; Pucci, Marzia; Passiglia, Francesco; Taverna, Simona; Taverna, Simona; Jantus-Lewintre, Eloisa; Naing, Aung; Khan, Shahanavaj; Pucci, Marzia; Duréndez Sáez, Elena; Malarani, Mahafarin; Reclusa Asiáin, Pablo; Rolfo, Christian; Raez, Luis E.

In: Targeted Oncology, 2018.

Risultato della ricerca: Article

Reclusa Asiain, P, Fontana, S, Pucci, M, Passiglia, F, Taverna, S, Taverna, S, Jantus-Lewintre, E, Naing, A, Khan, S, Pucci, M, Duréndez Sáez, E, Malarani, M, Reclusa Asiáin, P, Rolfo, C & Raez, LE 2018, 'Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression', Targeted Oncology.
Reclusa Asiain, Pablo ; Fontana, Simona ; Pucci, Marzia ; Passiglia, Francesco ; Taverna, Simona ; Taverna, Simona ; Jantus-Lewintre, Eloisa ; Naing, Aung ; Khan, Shahanavaj ; Pucci, Marzia ; Duréndez Sáez, Elena ; Malarani, Mahafarin ; Reclusa Asiáin, Pablo ; Rolfo, Christian ; Raez, Luis E. / Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression. In: Targeted Oncology. 2018.
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abstract = "Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.",
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AU - Reclusa Asiain, Pablo

AU - Fontana, Simona

AU - Pucci, Marzia

AU - Passiglia, Francesco

AU - Taverna, Simona

AU - Taverna, Simona

AU - Jantus-Lewintre, Eloisa

AU - Naing, Aung

AU - Khan, Shahanavaj

AU - Pucci, Marzia

AU - Duréndez Sáez, Elena

AU - Malarani, Mahafarin

AU - Reclusa Asiáin, Pablo

AU - Rolfo, Christian

AU - Raez, Luis E.

PY - 2018

Y1 - 2018

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AB - Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.

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