Abstract
| Lingua originale | English |
|---|---|
| Numero di pagine | 13 |
| Rivista | Targeted Oncology |
| Stato di pubblicazione | Published - 2018 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
- Pharmacology (medical)
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Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression. / Reclusa Asiain, Pablo; Fontana, Simona; Pucci, Marzia; Passiglia, Francesco; Taverna, Simona; Taverna, Simona; Jantus-Lewintre, Eloisa; Naing, Aung; Khan, Shahanavaj; Pucci, Marzia; Duréndez Sáez, Elena; Malarani, Mahafarin; Reclusa Asiáin, Pablo; Rolfo, Christian; Raez, Luis E.
In: Targeted Oncology, 2018.Risultato della ricerca: Article
}
TY - JOUR
T1 - Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression
AU - Reclusa Asiain, Pablo
AU - Fontana, Simona
AU - Pucci, Marzia
AU - Passiglia, Francesco
AU - Taverna, Simona
AU - Taverna, Simona
AU - Jantus-Lewintre, Eloisa
AU - Naing, Aung
AU - Khan, Shahanavaj
AU - Pucci, Marzia
AU - Duréndez Sáez, Elena
AU - Malarani, Mahafarin
AU - Reclusa Asiáin, Pablo
AU - Rolfo, Christian
AU - Raez, Luis E.
PY - 2018
Y1 - 2018
N2 - Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.
AB - Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression.
UR - http://hdl.handle.net/10447/264354
M3 - Article
JO - Targeted Oncology
JF - Targeted Oncology
SN - 1776-2596
ER -