Extracellular vesicles as biological shuttles for targeted therapies

Riccardo Alessandro, Stefania Raimondo, Riccardo Alessandro, Aurelio Lorico, Gianluca Giavaresi

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)-specialized membrane-bound nanocarriers for intercellular communication-suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical issues to target them to specific cells/tissues/organs. Here, we will discuss the current developments in the field of animal and plant-derived EVs toward their potential use for delivery of therapeutic agents in different pathological conditions, with a special focus on cancer.
Lingua originaleEnglish
pagine (da-a)1848-1865
Numero di pagine18
RivistaInternational Journal of Molecular Sciences
Volume20
Stato di pubblicazionePublished - 2019

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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