Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases

Fabio Bucchieri, Federica Scalia, Daniela Carlisi, Claudia Campanella, Antonella Marino Gammazza, Celeste Caruso Bavisotto, Francesco Cappello, Antonella Marino Gammazza, Federica Scalia, Celeste Caruso Bavisotto, Everly Conway De Macario, Francesco Cappello, Alberto J. L. Macario

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.
Lingua originaleEnglish
pagine (da-a)434-
Numero di pagine23
RivistaInternational Journal of Molecular Sciences
Volume20
Stato di pubblicazionePublished - 2019

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Exosomes
nervous system
Neurology
Nervous System
communication
central nervous system
Tissue homeostasis
Communication
cells
Neurophysiology
Neurodegenerative diseases
Tissue
Nervous System Diseases
Molecules
neurophysiology
Physiology
disorders
bioengineering
Pathology
MicroRNAs

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo

Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases. / Bucchieri, Fabio; Scalia, Federica; Carlisi, Daniela; Campanella, Claudia; Marino Gammazza, Antonella; Caruso Bavisotto, Celeste; Cappello, Francesco; Gammazza, Antonella Marino; Scalia, Federica; Bavisotto, Celeste Caruso; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J. L.

In: International Journal of Molecular Sciences, Vol. 20, 2019, pag. 434-.

Risultato della ricerca: Article

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AU - Carlisi, Daniela

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AU - Marino Gammazza, Antonella

AU - Caruso Bavisotto, Celeste

AU - Cappello, Francesco

AU - Gammazza, Antonella Marino

AU - Scalia, Federica

AU - Bavisotto, Celeste Caruso

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J. L.

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