Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases

Fabio Bucchieri, Federica Scalia, Daniela Carlisi, Claudia Campanella, Celeste Caruso Bavisotto, Antonella Marino Gammazza, Francesco Cappello, Antonella Marino Gammazza, Federica Scalia, Celeste Caruso Bavisotto, Everly Conway De Macario, Francesco Cappello, Alberto J. L. Macario

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.
Lingua originaleEnglish
pagine (da-a)434-
Numero di pagine23
RivistaDefault journal
Volume20
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo

Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases. / Bucchieri, Fabio; Scalia, Federica; Carlisi, Daniela; Campanella, Claudia; Caruso Bavisotto, Celeste; Marino Gammazza, Antonella; Cappello, Francesco; Gammazza, Antonella Marino; Scalia, Federica; Bavisotto, Celeste Caruso; De Macario, Everly Conway; Cappello, Francesco; Macario, Alberto J. L.

In: Default journal, Vol. 20, 2019, pag. 434-.

Risultato della ricerca: Article

Bucchieri, Fabio ; Scalia, Federica ; Carlisi, Daniela ; Campanella, Claudia ; Caruso Bavisotto, Celeste ; Marino Gammazza, Antonella ; Cappello, Francesco ; Gammazza, Antonella Marino ; Scalia, Federica ; Bavisotto, Celeste Caruso ; De Macario, Everly Conway ; Cappello, Francesco ; Macario, Alberto J. L. / Extracellular vesicle-mediated cell–cell communication in the nervous system: Focus on neurological diseases. In: Default journal. 2019 ; Vol. 20. pagg. 434-.
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abstract = "Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.",
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AU - Carlisi, Daniela

AU - Campanella, Claudia

AU - Caruso Bavisotto, Celeste

AU - Marino Gammazza, Antonella

AU - Cappello, Francesco

AU - Gammazza, Antonella Marino

AU - Scalia, Federica

AU - Bavisotto, Celeste Caruso

AU - De Macario, Everly Conway

AU - Cappello, Francesco

AU - Macario, Alberto J. L.

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N2 - Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.

AB - Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.

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KW - Cell-cell interaction

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KW - Computer Science Applications1707 Computer Vision and Pattern Recognition

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KW - Inorganic Chemistry

KW - Molecular Biology

KW - Nervous system

KW - Neurological diseases

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

KW - Spectroscopy

KW - Theranostics tools

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