Extracellular matrix composition in COPD

Salvatore Battaglia, Tatiana Lanca̧S, Luiz Fernando Ferraz Da Silva, Raquel Annoni, Marcus De Medeiros Matsushita, Ryan Yukimatsu Tanigawa, Sandra De Morais Fernezlian, Marisa Dolhnikoff, Thais Mauad, Pieter S. Hiemstra, Peter J. Roughley, Klaus F. Rabe, Peter J. Sterk

Risultato della ricerca: Article

59 Citazioni (Scopus)

Abstract

Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 nonsmoking control subjects. The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and nonsmoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in nonsmokers. Compared with nonsmokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters. Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction.
Lingua originaleEnglish
pagine (da-a)1362-1373
Numero di pagine12
RivistaEuropean Respiratory Journal
Volume40
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Fingerprint Entra nei temi di ricerca di 'Extracellular matrix composition in COPD'. Insieme formano una fingerprint unica.

  • Cita questo

    Battaglia, S., Lanca̧S, T., Da Silva, L. F. F., Annoni, R., Matsushita, M. D. M., Tanigawa, R. Y., Fernezlian, S. D. M., Dolhnikoff, M., Mauad, T., Hiemstra, P. S., Roughley, P. J., Rabe, K. F., & Sterk, P. J. (2012). Extracellular matrix composition in COPD. European Respiratory Journal, 40, 1362-1373.