Extra-Intestinal Fluoroquinolone-Resistant Escherichia coli Strains Isolated from Meat

Giuseppina Capra, Teresa Maria Assunta Fasciana, Anna Giammanco, Giuseppa Oliveri, Cinzia Cardamone

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Extra-intestinalE.coliareemergingasaglobalthreatduetotheirdiffusionasopportunisticpathogensand,aboveall,totheirwide setofantibioticresistancedeterminants.Therearestillmanygapsinourknowledgeoftheiroriginandspreadpathways,although food animalshavebeenadjudicatedvehiclesfor passingmult-drugresistantbacteriatohumans.Thisstudyanalyzed 46samples of meat purchasedfrom retail stores in Palermo in order toobtain quinolone-resistant E. coli isolates. Strains were screenedfor their phylogeneticgroups, ST131-associatedsingle nucleotidepolymorphisms (SNPs),andthentypedbyERIC-PCR. Theirsetof virulencefactors,namely,kpsMII,papA,sfaS,focG,iutA,papC,hlyD,andafagenes,wereinvestigatedandtheirfluoroquinoloneresistancedeterminantsevaluated.Thedataobtainedshowadramaticallyhighprevalenceofmultidrugresistancepatternsinthe Palermoarea,with28%oftheisolateshavingvirulencefactorgenestypicalofExPEC strains.NoB2grouporST131 strainswere detected.Moreover,20%ofourisolatesshowedpositivitytoalltheplasmid-mediatedquinoloneresistance(PMQR)determinants, showingapotentialtotransferthesegenesamongotherbacteria.Therefore,thesedataunderlinethepossibilitythatfoodanimals and,specifically,poultryinparticularmaybeasignificantsourceofresistantbacterialstrains,posingapotentialzoonoticrisk.
Lingua originaleEnglish
Numero di pagine8
RivistaBioMed Research International
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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