Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases

Rosa Maria Tomasino, Antonio Russo, Francesco Pantano, Donatella Grasso, Ilaria Roato, Alessandro Del Conte, Camillo Porta, Chiara Della Pepa, Andrea Onetti Muda, Andrea Onetti Muda, Giuseppe Perrone, Gaia Schiavon, Maria Elisabetta Fratto, Nicola Papapietro, Laura Godio, Roberto Sabbatini, Bruno Vincenzi, Vincenzo Denaro, Alfredo Berruti, Mauro PapottiGiuseppe Tonini, Daniele Santini

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Abstract

Receptor activator of NFκB ligand (RANKL), RANK, and osteoprotegerin (OPG) represent the key regulators of bone metabolism both in normal and pathological conditions, including bone metastases. To our knowledge, no previous studies investigated and compared RANK expression in primary tumors and in bone metastases from the same patient. We retrospectively examined RANK expression by immunohistochemistry in 74 bone metastases tissues from solid tumors, mostly breast, colorectal, renal, lung, and prostate cancer. For 40 cases, tissue from the corresponding primary tumor was also analyzed. Sixty-six (89%) of the 74 bone metastases were RANK-positive and, among these, 40 (59.5%) showed more than 50% of positive tumor cells. The median percentage of RANK-positive cells was 60% in primary tumors and metastases, without any statistically significant difference between the two groups (P = 0.194). The same percentage was obtained by considering only cases with availability of samples both from primary and metastasis. Our study shows that RANK is expressed by solid tumors, with high concordance between bone metastasis and corresponding primary tumor. These data highlight the central role of RANK/RANKL/OPG pathway as potential therapeutic target not only in bone metastasis management, but also in the adjuvant setting.
Lingua originaleEnglish
pagine (da-a)780-784
Numero di pagine5
RivistaJournal of Cellular Physiology
Volume226
Stato di pubblicazionePublished - 2011

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cita questo

Tomasino, R. M., Russo, A., Pantano, F., Grasso, D., Roato, I., Del Conte, A., Porta, C., Della Pepa, C., Onetti Muda, A., Onetti Muda, A., Perrone, G., Schiavon, G., Fratto, M. E., Papapietro, N., Godio, L., Sabbatini, R., Vincenzi, B., Denaro, V., Berruti, A., ... Santini, D. (2011). Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases. Journal of Cellular Physiology, 226, 780-784.