TY - JOUR
T1 - Expression pattern of estroprogestinic receptors in sinonasal inverted papilloma
AU - Gallina, Salvatore
AU - Spinato, Giacomo
AU - Castro, Veronica
AU - Mauro, Paola Di
AU - Licciardello, Luisa
AU - Conti, Angelo
AU - Serra, Agostino
AU - Caltabiano, Rosario
AU - Maiolino, Luigi
AU - Lanzafame, Salvatore
AU - Cocuzza, Salvatore
AU - Rapisarda, Venerando
AU - Caruso, Salvatore
PY - 2017
Y1 - 2017
N2 - Inverted papilloma (IP) is a locally destructive, benign neoplasm of the nose and paranasal sinuses with a high tendency for recurrence, a significant potential for malignancy, and an etiology that today is still uncertain. The expression of hormonal receptors in neoplastic tissues has been the focus of intensive research for its potential diagnostic, prognostic, and therapeutic significance. The aim of this study was to assess the potential estroprogestinic receptor expression in patients undergoing sinus surgery for IP. A retrospective study was carried out, on surgical specimens of 73 patients who underwent endoscopic sinus surgery for first manifestation of sinonasal IP (primitive IP group) and in 21 subjects who had developed a recurrence (relapsed IP group). The results of the immunohistochemical analysis of the first group showed the absence of receptor expression for PGR in all cases analyzed and the presence of a low positivity for ER in 11 cases (P > 0.082). Similarly, in the second group the results showed a low presence of ER receptors in 3 of the 21 cases (P > 0.068), while there was no evidence of PGR receptors in the examined samples. In addition, in 11 of the cases only 3 were considered positive (27.2%) showing a recurrence during follow-up (P > 0.068). Our results suggest that the sinonasal IP is a benign tumor independent of estrogen and progesterone, and the receptors for these hormones are therefore unsuitable as predictors of relapse or possible prognostic indicators and therapeutic targets.
AB - Inverted papilloma (IP) is a locally destructive, benign neoplasm of the nose and paranasal sinuses with a high tendency for recurrence, a significant potential for malignancy, and an etiology that today is still uncertain. The expression of hormonal receptors in neoplastic tissues has been the focus of intensive research for its potential diagnostic, prognostic, and therapeutic significance. The aim of this study was to assess the potential estroprogestinic receptor expression in patients undergoing sinus surgery for IP. A retrospective study was carried out, on surgical specimens of 73 patients who underwent endoscopic sinus surgery for first manifestation of sinonasal IP (primitive IP group) and in 21 subjects who had developed a recurrence (relapsed IP group). The results of the immunohistochemical analysis of the first group showed the absence of receptor expression for PGR in all cases analyzed and the presence of a low positivity for ER in 11 cases (P > 0.082). Similarly, in the second group the results showed a low presence of ER receptors in 3 of the 21 cases (P > 0.068), while there was no evidence of PGR receptors in the examined samples. In addition, in 11 of the cases only 3 were considered positive (27.2%) showing a recurrence during follow-up (P > 0.068). Our results suggest that the sinonasal IP is a benign tumor independent of estrogen and progesterone, and the receptors for these hormones are therefore unsuitable as predictors of relapse or possible prognostic indicators and therapeutic targets.
KW - Hormonal receptor expression
KW - Human papilloma virus
KW - Immunohistochemistry
KW - Inverted papilloma
KW - Oncology
KW - Paranasal sinuses
KW - Hormonal receptor expression
KW - Human papilloma virus
KW - Immunohistochemistry
KW - Inverted papilloma
KW - Oncology
KW - Paranasal sinuses
UR - http://hdl.handle.net/10447/251842
UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=17161&path%5B%5D=54943
M3 - Article
VL - 8
SP - 38962
EP - 38968
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
ER -