Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons

Giuseppe Salemi, Giovanni Savettieri, Italia Di Liegro, Massimo Coppolino, Alessandro Cestelli, Maria Scaturro, Tommaso Nastasi, Daniele Castiglia, Italia Di Liegro, Alessandro Cestelli

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13 Citazioni (Scopus)

Abstract

Synapsin I is a neuron-specific protein which is present in two isoforms, Ia and Ib. In the last few years this protein has been demonstrated to play a central role in the regulation of neurotransmitter release and synaptic plasticity. In this paper the developmental expression of this protein has been investigated in primary neuronal cultures from fetal rat brain cortices. The presence of thyroid hormone in the culture medium stimulates an early expression of the protein without exerting any effect at the level of mRNA transcription and accumulation. These observations implicate a T3-dependent regulation of this neuron-specific gene at the level of mRNA translation. © 1995 Plenum Publishing Corporation.
Lingua originaleEnglish
pagine (da-a)239-243
Numero di pagine5
RivistaNeurochemical Research
Volume20
Stato di pubblicazionePublished - 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    Salemi, G., Savettieri, G., Di Liegro, I., Coppolino, M., Cestelli, A., Scaturro, M., Nastasi, T., Castiglia, D., Di Liegro, I., & Cestelli, A. (1995). Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons. Neurochemical Research, 20, 239-243.