Expression of sexual hormones receptors in oral squamous cell carcinoma

Giuseppina Campisi, D'Amato, Ferrara, Izzo, Carinci, Cannavale, Mazzotta, Minucci, Giuseppe Colella, Lorenzo Lo Muzio

Risultato della ricerca: Article

11 Citazioni (Scopus)

Abstract

Sexual hormones play an important role in expression of genes involved in a wide variety of biological and neoplastic processes. The information on Estrogen Receptors (ER) expression in non-target tissues is very few and, in particular, the studies in head and neck tumors are still controversial. Recent studies analyzed the role of Tamoxifen (TAM) on Oral Squamous Cell Carcinoma (OSCC) lines in relation to the presence/absence of ER. The purpose of the present study was to evaluate the expression of sexual hormones receptors mRNAs, in particular Estrogen Receptor alpha (ERα) and Androgen Receptor (AR) mRNA in OSCC tissues. The study group comprised 20 samples of OSCC, harvested from 20 otherwise healthy subjects (14 males and 6 females, mean age 58.2y, range 38-74). The control group was formed by 20 samples of normal mucosa harvested around the margins of the specimens (at least 1 cm from the lesion margins). Estrogens Receptor alpha (Era) and Androgen Receptor (AR) mRNA expressions were analyzed by RT-PCR carried out on total RNAs extracted from both cancerous and healthy tissues. Obtained data were evaluated by Shapiro-Walk normality test and compared by Student's t test. Results with p<0.05 were considered statistically significant. AR transcripts were less expressed in OSCC specimens than in healthy tissues, while levels of ERα transcripts significantly increased in tumor samples. These preliminary data show different expression patterns of AR and ERα mRNAs in malignant tissues of oral mucosa and could suggest an involvement of these sexual hormones in oral cancer
Lingua originaleEnglish
pagine (da-a)129-132
Numero di pagine4
RivistaInternational Journal of Immunopathology and Pharmacology
Volume24
Stato di pubblicazionePublished - 2011

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Androgen Receptors
Squamous Cell Carcinoma
Hormones
Messenger RNA
Estrogen Receptor alpha
Estrogen Receptors
Neoplastic Processes
Biological Phenomena
Mouth Neoplasms
Mouth Mucosa
Tamoxifen
Neoplasms
Healthy Volunteers
Mucous Membrane
Neck
Head
RNA
Students
Gene Expression
Cell Line

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pharmacology
  • Immunology

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Expression of sexual hormones receptors in oral squamous cell carcinoma. / Campisi, Giuseppina; D'Amato; Ferrara; Izzo; Carinci; Cannavale; Mazzotta; Minucci; Colella, Giuseppe; Lo Muzio, Lorenzo.

In: International Journal of Immunopathology and Pharmacology, Vol. 24, 2011, pag. 129-132.

Risultato della ricerca: Article

Campisi, G, D'Amato, Ferrara, Izzo, Carinci, Cannavale, Mazzotta, Minucci, Colella, G & Lo Muzio, L 2011, 'Expression of sexual hormones receptors in oral squamous cell carcinoma', International Journal of Immunopathology and Pharmacology, vol. 24, pagg. 129-132.
Campisi, Giuseppina ; D'Amato ; Ferrara ; Izzo ; Carinci ; Cannavale ; Mazzotta ; Minucci ; Colella, Giuseppe ; Lo Muzio, Lorenzo. / Expression of sexual hormones receptors in oral squamous cell carcinoma. In: International Journal of Immunopathology and Pharmacology. 2011 ; Vol. 24. pagg. 129-132.
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