IAPs (inhibitors of apoptosis proteins) might have a major role inthe apoptotic resistance that marks many cancers. The studies on IAPs in humanHCC have focused on survivin or XIAP, indicating that their new or increasedexpression in this tumor is associated with a more unfavorableprognosis. The present results corroborate these findings, emphasizing the rolethat the coordinated expression of different IAPs and alternative splice variantsmight play in the adverse biology of hepatocellular carcinoma.
|Numero di pagine||5|
|Rivista||Annals of the New York Academy of Sciences|
|Stato di pubblicazione||Published - 2004|
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