Expression of Gelatinases (MMP-2, MMP-9) in human articular cartilage

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Abstract

Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis. The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunihistochemistry. Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.
Lingua originaleEnglish
pagine (da-a)817-823
Numero di pagine7
RivistaInternational Journal of Immunopathology and Pharmacology
Volume26
Stato di pubblicazionePublished - 2013

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Gelatinases
Matrix Metalloproteinase 2
Articular Cartilage
Osteoarthritis
Matrix Metalloproteinases
Cartilage
Joints
Synovitis
Matrix Metalloproteinase 9
human MMP9 protein
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pharmacology
  • Immunology

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title = "Expression of Gelatinases (MMP-2, MMP-9) in human articular cartilage",
abstract = "Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis. The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunihistochemistry. Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.",
author = "Aldo Gerbino and Luana Lipari",
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language = "English",
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journal = "International Journal of Immunopathology and Pharmacology",
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AU - Gerbino, Aldo

AU - Lipari, Luana

PY - 2013

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N2 - Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis. The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunihistochemistry. Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.

AB - Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis. The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunihistochemistry. Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.

UR - http://hdl.handle.net/10447/84166

M3 - Article

VL - 26

SP - 817

EP - 823

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

ER -