Ubiquitous system of regulatory, calcium-dependent, cytoplasmic proteases – calpains – and theirendogenous inhibitor – calpastatin – is implicated in the proteolytic regulation of activation, proliferation, andapoptosis of many cell types. However, it has not been thoroughly studied in resting and activated humanlymphocytes yet, especially in relation to the subjects’ ageing process. The CALPACENT project is an international(Polish-Italian) project aiming at verifying the hypothesis of the role of calpains in the function of peripheral bloodimmune cells of Polish (Pomeranian) and Italian (Sicilian) centenarians, apparently relatively preserved in comparisonto the general elderly population. In this preliminary report we aimed at establishing and comparing the baselinelevels of expression of μ- and m-calpain and calpastatin in various, phenotypically defined, populations of humanperipheral blood lymphocytes for healthy elderly Sicilians and Poles, as compared to these values observed inyoung cohort.
|Numero di pagine||8|
|Rivista||IMMUNITY & AGEING|
|Stato di pubblicazione||Published - 2013|
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