Expression analysis of jagged genes in zebrafish embryos

Alice Conigliaro, Alice Conigliaro, Elisabetta Zecchin, Natascia Tiso, Francesco Argenton, Marino Bortolussi

Risultato della ricerca: Article

32 Citazioni (Scopus)

Abstract

The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Conversely, jagged1a and jagged2, both widely expressed in the central nervous system, are not coexpressed. jagged2 is also detected in the epidermis, newly formed somites, pharyngeal pouches, and pancreatic exocrine anlage and jagged1b in otic placodes and cell clusters close to the pancreatic islet. The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes © 2005 Wiley-Liss, Inc.
Lingua originaleEnglish
pagine (da-a)638-645
Numero di pagine8
RivistaDevelopmental Dynamics
Volume233
Stato di pubblicazionePublished - 2005

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Zebrafish
Embryonic Structures
Genes
Ear
Pronephros
Notch Receptors
Ligands
Notochord
Somites
Islets of Langerhans
Epidermis
Lenses
In Situ Hybridization
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Developmental Biology

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Conigliaro, A., Conigliaro, A., Zecchin, E., Tiso, N., Argenton, F., & Bortolussi, M. (2005). Expression analysis of jagged genes in zebrafish embryos. Developmental Dynamics, 233, 638-645.

Expression analysis of jagged genes in zebrafish embryos. / Conigliaro, Alice; Conigliaro, Alice; Zecchin, Elisabetta; Tiso, Natascia; Argenton, Francesco; Bortolussi, Marino.

In: Developmental Dynamics, Vol. 233, 2005, pag. 638-645.

Risultato della ricerca: Article

Conigliaro, A, Conigliaro, A, Zecchin, E, Tiso, N, Argenton, F & Bortolussi, M 2005, 'Expression analysis of jagged genes in zebrafish embryos', Developmental Dynamics, vol. 233, pagg. 638-645.
Conigliaro A, Conigliaro A, Zecchin E, Tiso N, Argenton F, Bortolussi M. Expression analysis of jagged genes in zebrafish embryos. Developmental Dynamics. 2005;233:638-645.
Conigliaro, Alice ; Conigliaro, Alice ; Zecchin, Elisabetta ; Tiso, Natascia ; Argenton, Francesco ; Bortolussi, Marino. / Expression analysis of jagged genes in zebrafish embryos. In: Developmental Dynamics. 2005 ; Vol. 233. pagg. 638-645.
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abstract = "The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Conversely, jagged1a and jagged2, both widely expressed in the central nervous system, are not coexpressed. jagged2 is also detected in the epidermis, newly formed somites, pharyngeal pouches, and pancreatic exocrine anlage and jagged1b in otic placodes and cell clusters close to the pancreatic islet. The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes {\^A}{\circledC} 2005 Wiley-Liss, Inc.",
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T1 - Expression analysis of jagged genes in zebrafish embryos

AU - Conigliaro, Alice

AU - Conigliaro, Alice

AU - Zecchin, Elisabetta

AU - Tiso, Natascia

AU - Argenton, Francesco

AU - Bortolussi, Marino

PY - 2005

Y1 - 2005

N2 - The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Conversely, jagged1a and jagged2, both widely expressed in the central nervous system, are not coexpressed. jagged2 is also detected in the epidermis, newly formed somites, pharyngeal pouches, and pancreatic exocrine anlage and jagged1b in otic placodes and cell clusters close to the pancreatic islet. The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes © 2005 Wiley-Liss, Inc.

AB - The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Conversely, jagged1a and jagged2, both widely expressed in the central nervous system, are not coexpressed. jagged2 is also detected in the epidermis, newly formed somites, pharyngeal pouches, and pancreatic exocrine anlage and jagged1b in otic placodes and cell clusters close to the pancreatic islet. The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes © 2005 Wiley-Liss, Inc.

KW - Cell Biology

KW - Developmental Biology

KW - Embryo

KW - In situ hybridization

KW - Jagged/serrate genes

KW - Nervous system

KW - Notch signaling

KW - Notochord

KW - Pancreas

KW - Placodes

KW - Pronephros

KW - Somites

KW - Vertebrate

KW - Zebrafish

UR - http://hdl.handle.net/10447/241695

M3 - Article

VL - 233

SP - 638

EP - 645

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

ER -