Exposure to cytotoxic concentrations of manganese and effects on development

Risultato della ricerca: Other contribution

Abstract

Manganese is one of the most abundant metals present in nature in trace amounts, which is accumulated and utilized by all forms of life. It plays a multitude of biological roles, but exposure of cells/organisms to high levels causes toxicity. In the marine environment, increasing concentrations of bio-available ions often result from anthropogenic activities, and, consequently, manganese represents a new emergent factor in environmental contamination. To study cyto-toxicity of manganese on development, we used an excellent model system as sea urchin embryos Paracentrotus lividus. In this work, we show results from two-dimensional gel electrophoresis (2DE) analysis that highlighted qualitative/quantitative patterns of protein spots differences in control and manganese-exposed embryos.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2009

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manganese
embryo
marine environment
electrokinesis
human activity
gel
toxicity
protein
exposure
effect
ion
metal

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title = "Exposure to cytotoxic concentrations of manganese and effects on development",
abstract = "Manganese is one of the most abundant metals present in nature in trace amounts, which is accumulated and utilized by all forms of life. It plays a multitude of biological roles, but exposure of cells/organisms to high levels causes toxicity. In the marine environment, increasing concentrations of bio-available ions often result from anthropogenic activities, and, consequently, manganese represents a new emergent factor in environmental contamination. To study cyto-toxicity of manganese on development, we used an excellent model system as sea urchin embryos Paracentrotus lividus. In this work, we show results from two-dimensional gel electrophoresis (2DE) analysis that highlighted qualitative/quantitative patterns of protein spots differences in control and manganese-exposed embryos.",
keywords = "manganese, sea urchin embryos, two-dimensional protein patterns.",
author = "Roccheri, {Maria Carmela} and Liana Bosco and Annalisa Pinsino",
year = "2009",
language = "English",
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TY - GEN

T1 - Exposure to cytotoxic concentrations of manganese and effects on development

AU - Roccheri, Maria Carmela

AU - Bosco, Liana

AU - Pinsino, Annalisa

PY - 2009

Y1 - 2009

N2 - Manganese is one of the most abundant metals present in nature in trace amounts, which is accumulated and utilized by all forms of life. It plays a multitude of biological roles, but exposure of cells/organisms to high levels causes toxicity. In the marine environment, increasing concentrations of bio-available ions often result from anthropogenic activities, and, consequently, manganese represents a new emergent factor in environmental contamination. To study cyto-toxicity of manganese on development, we used an excellent model system as sea urchin embryos Paracentrotus lividus. In this work, we show results from two-dimensional gel electrophoresis (2DE) analysis that highlighted qualitative/quantitative patterns of protein spots differences in control and manganese-exposed embryos.

AB - Manganese is one of the most abundant metals present in nature in trace amounts, which is accumulated and utilized by all forms of life. It plays a multitude of biological roles, but exposure of cells/organisms to high levels causes toxicity. In the marine environment, increasing concentrations of bio-available ions often result from anthropogenic activities, and, consequently, manganese represents a new emergent factor in environmental contamination. To study cyto-toxicity of manganese on development, we used an excellent model system as sea urchin embryos Paracentrotus lividus. In this work, we show results from two-dimensional gel electrophoresis (2DE) analysis that highlighted qualitative/quantitative patterns of protein spots differences in control and manganese-exposed embryos.

KW - manganese

KW - sea urchin embryos

KW - two-dimensional protein patterns.

UR - http://hdl.handle.net/10447/60309

M3 - Other contribution

ER -