Exploring the Virchow-Robin spaces function: A unified theory of brain diseases

Giovanni Grasso, Iype Cherian, Binod Bhattarai, Sunil Munokami, Margarita Beltran, Ekkehard M. Kasper

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)


Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .
Lingua originaleEnglish
pagine (da-a)S711-S714
Numero di pagine4
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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