TY - JOUR
T1 - Exploring the Virchow-Robin spaces function: A unified theory of brain diseases
AU - Grasso, Giovanni
AU - Cherian, Iype
AU - Bhattarai, Binod
AU - Munokami, Sunil
AU - Beltran, Margarita
AU - Kasper, Ekkehard M.
PY - 2016
Y1 - 2016
N2 - Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .
AB - Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different pathological conditions. Conclusion: The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure. ©2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow .
UR - http://hdl.handle.net/10447/414262
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009288495&doi=10.4103/2152-7806.192486&partnerID=40&md5=ca1ebd56a0dafb65a9c6bcd1c3697695
M3 - Article
VL - 7
SP - S711-S714
JO - SURGICAL NEUROLOGY INTERNATIONAL
JF - SURGICAL NEUROLOGY INTERNATIONAL
SN - 2229-5097
ER -