Exploratory study on the effects of biodegradable nanoparticles with drugs on malignant B cells and on a human/mouse model of Burkitt lymphoma.

Claudio Tripodo, Sabrina Ingrao, Francesco Tedesco, Alberto Maceira, Nelly Mezzaroba, Ruben Spret, José M. Tau, Carol Mertz, Luis Núñez, Paolo Macor, Sonia Zorzet, Gustavo Larsen, Gustavo H. Marín, Eduardo Mansilla

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

The aim of this study was to determine if Rituximab coated Biodegradable Nanoparticles (BNPs) loaded with Chlorambucil and Hydroxychloroquine could induce apoptosis of B-Chronic Lymphocytic Leukemia (B-CLL), MEC-1 and BJAB cells in vitro and evaluate their toxic and therapeutic effects on a Human/Mouse Model of Burkitt Lymphoma at an exploratory, proof of concept scale. We found that Rituximab-Chlorambucil-Hydroxychloroquine BNPs induce a decrease in cell viability of malignant B cells in a dose-dependent manner. The mediated cytotoxicity resulted from apoptosis, and was confirmed by monitoring the B-CLL cells after Annexin V/propidium iodide staining. Additional data revealed that these BNPs were non toxic for healthy animals, and had prolonged survival in this mice model of human lymphoma.
Lingua originaleEnglish
pagine (da-a)246-250
Numero di pagine5
RivistaCurrent Clinical Pharmacology
Volume5
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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Tripodo, C., Ingrao, S., Tedesco, F., Maceira, A., Mezzaroba, N., Spret, R., Tau, J. M., Mertz, C., Núñez, L., Macor, P., Zorzet, S., Larsen, G., Marín, G. H., & Mansilla, E. (2010). Exploratory study on the effects of biodegradable nanoparticles with drugs on malignant B cells and on a human/mouse model of Burkitt lymphoma. Current Clinical Pharmacology, 5, 246-250.