Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study

Carlo Maria Barbagallo, Pietro Cirillo, Guido Grassi, Massimo Cirillo, Francesca Mallamaci, Alessandro Maloberti, Loreto Gesualdo, Rita Facchetti, Paolo Pauletto, Lanfranco D’Elia, Giulia Rivasi, Massimo Volpe, Guido Iaccarino, Bruno Bernardino, Giovambattista Desideri, Guido Iaccarino, Lanfranco D’Elia, Massimo Cirillo, Stefano Masi, Lanfranco D’EliaLanfranco D’Elia, Lanfranco D’Elia, Guido Iaccarino, Lanfranco D’Elia, Lanfranco D’Elia, Paolo Verdecchia, Agostino Virdis, Guido Iaccarino, Francesca Viazzi, Michele Bombelli, Valerie Tikhonoff, Giuliano Tocci, Arrigo F. G. Cicero, Roberto Pontremoli, Pietro Nazzaro, Marcello Rattazzi, Guido Iaccarino, Maria Lorenza Muiesan, Agostino Virdis, Massimo Salvetti, Edoardo Casiglia, Cristina Giannattasio, Ferruccio Galletti, Alberto Mazza, Carlo M. Barbagallo, Andrea Ungar, Massimo Volpe, Paolo Palatini, Paolo Verdecchia, Claudio Borghi, Enrico Agabiti Rosei, Claudio Ferri

Risultato della ricerca: Articlepeer review

13 Citazioni (Scopus)


The relevance of cardiovascular role played by levels of serum uric acid is dramatically growing, especially as cardiovascular risk factor potentially able to exert either a direct deleterious impact or a synergic effect with other cardiovascular risk factors. At the present time, it still remains undefined the threshold level of serum uric acid able to contribute to the cardiovascular risk. Indeed, the available epidemiological case studies are not homogeneous, and some preliminary data suggest that the so-called "cardiovascular threshold limit" may substantially differ from that identified as a cut-off able to trigger the acute gout attack. In such scenario, there is the necessity to clarify and quantify this threshold value, to insert it in the stratification of risk algorithm scores and, in turn, to adopt proper prevention and correction strategies. The clarification of the relationship between circulating levels of uric acid and cardio-nephro-metabolic disorders in a broad sample representative of general population is critical to identify the threshold value of serum uric acid better discriminating the increased risk associated with uric acid. The Uric acid Right for heArt Health (URRAH) project has been designed to define, as primary objective, the level of uricemia above which the independent risk of cardiovascular disease may increase in a significantly manner in a general Italian population.
Lingua originaleEnglish
pagine (da-a)197-202
Numero di pagine6
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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