Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection

Anna Licata, Maurizio Cotrufo, Massimo Trucco, William Rudert, Anna Licata, Gianluigi Condorelli, Sara Riboni, Dawn Betters, Giacomo Frati, Patrizia Luppi

Risultato della ricerca: Article

13 Citazioni (Scopus)

Abstract

Idiopathic dilated cardiomyopathy (IDC) is one of the major causes of death in humans and has been linked to Coxsackievirus B (CVB) infection. The aim of this study was to analyze phenotypes of heart-infiltrating immune cells in patients suffering from myocarditis and IDC associated with CVB infections. We found that the myocardium of these patients was infiltrated by CD4(+) and CD8(+) T lymphocytes as well as macrophages. Evidence of CVB3/4 infections was also found. In the majority of patients, the T-cell receptor repertoire (TCR) of the infiltrating lymphocytes was restricted, with a polyclonal expansion of the Vbeta7 gene family. We also found that human leukocyte antigen (HLA) class II alleles associated with susceptibility to type 1 diabetes (HLA-DR4 and HLA-DQA1*04/05/06 alleles) were remarkably infrequent in IDC patients (p < 0.005), thus suggesting that they might confer protection against IDC. Finally, mRNA for interleukin-1beta, interferon-gamma, and tumor necrosis factor-alpha was detected in the cardiac specimens, although at a lower level compared with specimens from hearts without signs of viral infections. We conclude that CVB infection of the human myocardium is associated with a selective, yet polyclonal activation of different T-cell subsets in genetically susceptible individuals. This immune response may play a critical role in modulating disease progression after viral infections.
Lingua originaleEnglish
pagine (da-a)194-210
Numero di pagine17
RivistaHuman Immunology
Volume64
Stato di pubblicazionePublished - 2003

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Licata, A., Cotrufo, M., Trucco, M., Rudert, W., Licata, A., Condorelli, G., Riboni, S., Betters, D., Frati, G., & Luppi, P. (2003). Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection. Human Immunology, 64, 194-210.